Overview
- Authors:
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Peter J. Elsen
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Department of Immunohematology and Blood Bank, University Hospital Leiden, Leiden, The Netherlands
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Table of contents (8 chapters)
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- Linda Struyk, Gail E. Hawes, Frank Raaphorst, Marja van Eggermond, Barbara Godthelp, Peter J. van den Elsen
Pages 29-61
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- Gail E. Hawes, Peter J. van den Elsen
Pages 63-84
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- James T. Kurnick, Makiko Kumagai-Braesch, Carol P. Leary, Richard Waitkus, Lenora A. Boyle, Peter J. van den Elsen et al.
Pages 85-100
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- Benito A. Yard, Thomas Reterink, Peter J. van den Elsen, M. E. Paape, Jan Antony Bruijn, Leendert A. van Es et al.
Pages 101-115
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- Gert Datema, Len Vaessen, Rene Daane, Carla Baan, Willem Weimar, Frans Claas et al.
Pages 117-147
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- Benito A. Yard, Thomas Reterink, Jan Antony Bruijn, Peter J. van den Eisen, Frans J. Claas, Mohamed R. Daha et al.
Pages 149-162
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Back Matter
Pages 169-173
About this book
these analyses it became clear that the MHC class I molecule com prised a distinct groove on the external side of the molecule. The sides of the groove are formed by the a-helical structures of the a and a 1 2 domains and a floor which is formed by 8 anti-parallel 13 strands. The various polymorphic residues, as determined from DNA sequence analysis, are localized within these a-helices and 13-plated sheets within the groove. More importantly, these analyses also revealed the presence of elec tron-dense material in the groove. This material was subsequently iden 568 10 tified as a linear peptide of 8-10 amino acids long. • •- High resolu tion crystallographic analyses of the class I MHC structure have revealed the existence of so-called pockets within the grooves of the MHC class I molecules. These pockets designated A-F, exhibited allele-specificity and are directly involved in the binding of the peptide, primarily through interaction with the dominant anchor residues as found in MHC class I associated pep tides. 6,7,9,11 The class II MHC antigens consist on the cell surface of a 34 kD a chain non-covalently associated with a 28 kD 13 chain. With the excep tion of the DR a-chain, all other MHC class II a and 13 chains are poly morphic.
Authors and Affiliations
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Department of Immunohematology and Blood Bank, University Hospital Leiden, Leiden, The Netherlands
Peter J. Elsen
