Protein Toxin Structure

1. Front Matter

   Pages i-xv

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2. Introduction

   • Joseph E. Alouf

   Pages 1-4

3. Insights into Membrane Insertion Based on Studies of Colicins

   • Ingrid R. Vetter, Michael W. Parker, Franc Pattus, Demetrius Tsernoglou

   Pages 5-23

4. A Structure-Based Model of Diphtheria Toxin Action

   • David Eisenberg, Charles E. Bell, Melanie J. Bennett, R. John Collier, Michael P. Schlunegger, Boyd A. Steere et al.

   Pages 25-47

5. Insecticidal δ-Endotoxins from Bacillus Thuringiensis

   • Jade Li

   Pages 49-77

6. Structure and Assembly of the Channel-Forming Aeromonas Toxin Aerolysin

   • Michael W. Parker, J. Thomas Buckley, F. Gisou van der Goot, Demetrius Tsernoglou

   Pages 79-95

7. The Anthrax Toxin

   • Carlo Petosa, Robert C. Liddington

   Pages 97-121

8. The Cholera Family of Enterotoxins

   • David L. Scott, Rong-Guang Zhang, Edwin M. Westbrook

   Pages 123-146

9. E. Coli Heat Labile Enterotoxin and Cholera Toxin B-Pentamer—Crystallographic Studies of Biological Activity

   • Ethan A. Merritt, Focco van den Akker, Wim G. J. Hol

   Pages 147-172

10. Shiga Toxin

    • Marie E. Fraser, Maia M. Chernaia, Yuri V. Kozlov, Michael N. G. James

    Pages 173-190

11. Structural Insights into Pertussis Toxin Action

    • Penelope E. Stein, Bart Hazes, Randy J. Read

    Pages 191-216

12. Structure of Toxic Shock Syndrome Toxin-1

    • Douglas H. Ohlendorf, David T. Mitchell, G. Sridhar Prasad, R. Radhakrishnan, Cathleen A. Earhart, Patrick M. Schlievert

    Pages 217-229

13. Structure of Staphylococcal Enterotoxins

    • S. Swaminathan, William Furey, Martin Sax

    Pages 231-251

14. The Structure of Ribosome Inactivating Proteins from Plants

    • Jon D. Robertus, Arthur F. Monzingo

    Pages 253-270

15. The Structures and Evolution of Snake Toxins of the Three-Finger Folding Type

    • Dominique Housset, Juan C. Fontecilla-Camps

    Pages 271-290

16. The Structure of a Virally Encoded Fungal Toxin from Ustilago Maydis that Inhibits Fungal and Mammalian Calcium Channels

    • Fei Gu, Anis Khimani, Stan Rane, William H. Flurkey, Robert F. Bozarth, Thomas J. Smith

    Pages 291-303

17. Back Matter

    Pages 305-309

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Joseph E. Alouf "The empirical basis of objective science has thus nothing 'abso­ lute' about it. Science does not rest upon solid bedrock. The bold structure of its theories rises, as it were, above swamp. It is like a building erected on piles. The piles are driven down from above into the swamp, but not down to any natural or 'given' base; and if we stop driving the piles deeper, it is not because we have reached firm ground. We simply stop when we are satisfied that the piles are firm enough to carry the structure, at least for the time being. " -Karl Popper (The Logic of Scientific Discovery) hen I was invited to write this introductory chapter I was hon­ W ored and pleased to have the opportunity to briefly highlight some important issues relevant to structural aspects of bacterial protein tox­ ins. The present book attempts for the first time to provide into one volume a series of chapters prepared by invited experts on the struc­ ture of these fascinating macromolecules. A particular emphasis is placed on the molecular features of these highly active biomolecules in rela­ tion to their biological properties and mechanisms of action. The researchers in bacterial protein toxinology of my generation have had the privilege of witnessing over 40 years the tremen­ dous development of this field of biological sciences, particularly in the past decade.

• Termination
• ion channels
• membrane
• membrane ion channels
• protein
• proteins

• The Ian Potter Foundation Protein Crystallography Laboratory, St. Vincent’s Institute of Medical Research, Melbourne, Australia

  Michael W. Parker

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