Pre-mRNA Processing

1. Front Matter

   Pages N1-xii

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2. RNA Structure and Interactions With Proteins

   • David M. J. Lilley

   Pages 1-15

3. Functions of Nuclear Pre-mRNA/mRNA Binding Proteins

   • Maurice S. Swanson

   Pages 17-33

4. The Biochemistry of PRE-mRNA Splicing

   • Angela Krämer

   Pages 35-64

5. Pre-mRNA Splicing in Plants

   • Witold Filipowicz, Marek Gniadkowski, Ueli Klahre, Hong-Xiang Liu

   Pages 65-77

6. Yeast Splicing Factors and Genetic Strategies for Their Analysis

   • Jean D. Beggs

   Pages 79-95

7. Mechanisms of Regulated Pre-mRNA Splicing

   • Juan Valcárcel, Ravinder Singh, Michael R. Green

   Pages 97-112

8. 3′-End Cleavage and polyadenylation of nuclear Messenger RNA Precursors

   • Walter Keller

   Pages 113-134

9. Strategies for Regulating Nuclear pre-mRNA Polyadenylation

   • Anders Virtanen

   Pages 135-149

10. RNA Editing

    • James Scott

    Pages 151-161

11. Nuclear Organization of snRNPs and Splicing Factors

    • Maria Carmo-Fonseca, João Ferreira

    Pages 163-171

12. Export of mRNA Through the Nuclear Pore Complex

    • Wilbert C. Boelens, Catherine Dargemont, Iain W. Mattaj

    Pages 173-186

13. Clinical Defects in Pre-mRNA Processing

    • Michael Antoniou

    Pages 187-201

14. Viral Strategies Affecting RNA Processing in Mammalian Cells

    • J. Barklie Clements, Anne Phelan

    Pages 203-214

15. Back Matter

    Pages 215-223

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he past fifteen years have seen tremendous growth in our understanding of T the many post-transcriptional processing steps involved in producing func­ tional eukaryotic mRNA from primary gene transcripts (pre-mRNA). New processing reactions, such as splicing and RNA editing, have been discovered and detailed biochemical and genetic studies continue to yield important new insights into the reaction mechanisms and molecular interactions involved. It is now apparent that regulation of RNA processing plays a significant role in the control of gene expression and development. An increased understanding of RNA processing mechanisms has also proved to be of considerable clinical importance in the pathology of inherited disease and viral infection. This volume seeks to review the rapid progress being made in the study of how mRNA precursors are processed into mRNA and to convey the broad scope of the RNA field and its relevance to other areas of cell biology and medicine. Since one of the major themes of RNA processing is the recognition of specific RNA sequences and structures by protein factors, we begin with reviews of RNA-protein interactions. In chapter 1 David Lilley presents an overview of RNA structure and illustrates how the structural features of RNA molecules are exploited for specific recognition by protein, while in chapter 2 Maurice Swanson discusses the structure and function of the large family of hnRNP proteins that bind to pre-mRNA. The next four chapters focus on pre-mRNA splicing.

• Cell metabolism
• Protein Synthesis mRNA
• RNA
• RNA editing
• RNA-splicing
• cell
• gene
• metabolism
• protein
• protein synthesis
• synthesis
• yeast

• European Molecular Biology Laboratory, Heidelberg, Germany

  Angus I. Lamond

• Austin, USA

  R. G. Landes Company

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