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p53 Suppressor Gene

  • Book
  • © 1995

Overview

Authors:
  1. Tapas Mukhopadhyay

    1. M. D. Anderson Cancer Center, University of Texas, Houston, USA

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  2. Steven A. Maxwell

    1. M. D. Anderson Cancer Center, University of Texas, Houston, USA

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    You can also search for this author in PubMed   Google Scholar

  3. Jack A. Roth

    1. M. D. Anderson Cancer Center, University of Texas, Houston, USA

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Part of the book series: Molecular Biology Intelligence Unit (MBIU)

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Table of contents (6 chapters)

  1. Front Matter

    Pages i-xi
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  2. The Role of p53 in Cancer

    • Tapas Mukhopadhyay, Steven A. Maxwell, Jack A. Roth
    Pages 1-11

  3. Gene Structure

    • Tapas Mukhopadhyay, Steven A. Maxwell, Jack A. Roth
    Pages 13-18

  4. Wild-Type versus Mutant p53

    • Tapas Mukhopadhyay, Steven A. Maxwell, Jack A. Roth
    Pages 19-54

  5. Biophysical and Biochemical Properties of the p53 Protein

    • Tapas Mukhopadhyay, Steven A. Maxwell, Jack A. Roth
    Pages 55-72

  6. Regulation and Modulation of the Function of p53

    • Tapas Mukhopadhyay, Steven A. Maxwell, Jack A. Roth
    Pages 73-112

  7. Potential Clinical Significance of the p53 Tumor Suppressor Gene in Cancer Patients

    • Tapas Mukhopadhyay, Steven A. Maxwell, Jack A. Roth
    Pages 113-125

  8. Back Matter

    Pages 127-133
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Keywords

About this book

This book is about the p53 gene, one of the most frequently mutated or deleted genes in human cancers. The frequent occurrence of inactivated p53 implicates this gene product in the genesis of many human cancers. The p53 gene can suppress the growth of cancer cells and the transformation process by oncogenes. The p53 protein is a transcription factor that can repress or activate promoters containing one of three p53 DNA-binding motifs. The activity of p53 is regulated by phosphorylation and other transcription factors. Replacement of the p53 function or restoration of the p53 biochemical pathway is a focus of gene therapy.

Authors and Affiliations

  • M. D. Anderson Cancer Center, University of Texas, Houston, USA

    Tapas Mukhopadhyay, Steven A. Maxwell, Jack A. Roth

Bibliographic Information

  • Book Title: p53 Suppressor Gene

  • Authors: Tapas Mukhopadhyay, Steven A. Maxwell, Jack A. Roth

  • Series Title: Molecular Biology Intelligence Unit

  • DOI: https://doi.org/10.1007/978-3-662-22275-1

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1995

  • Softcover ISBN: 978-3-662-22277-5Published: 18 April 2014

  • eBook ISBN: 978-3-662-22275-1Published: 29 June 2013

  • Series ISSN: 1431-0414

  • Edition Number: 1

  • Number of Pages: XI, 132

  • Number of Illustrations: 6 b/w illustrations

  • Additional Information: Jointly published with R.G. Landes, Biomedical Publishers, Austin, USA

  • Topics: Cancer Research, Molecular Medicine

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