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Neurobiological Mechanisms of Opiate Withdrawal

  • Book
  • © 1996

Overview

Authors:
  1. Rafael Maldonado

    1. Pharmacochimie Moléculaire et Structurale, Paris, France

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  2. Luis Stinus

    1. Université de Bordeaux II, Bordeaux Cédex, France

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  3. George F. Koob

    1. The Scripps Research Institute, La Jolla, USA

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Part of the book series: Neuroscience Intelligence Unit (NIU.LANDES)

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Table of contents (8 chapters)

  1. Front Matter

    Pages i-xi
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  2. Historical Aspects

    • Rafael Maldonado, Luis Stinus, George F. Koob
    Pages 1-9

  3. Animal Models of Opiate Dependence

    • Rafael Maldonado, Luis Stinus, George F. Koob
    Pages 11-34

  4. Neurophysiology of Opiate Dependence

    • Rafael Maldonado, Luis Stinus, George F. Koob
    Pages 35-46

  5. Neurochemistry of Opiate Dependence

    • Rafael Maldonado, Luis Stinus, George F. Koob
    Pages 47-76

  6. Neuropsychopharmacology of Opiate Dependence

    • Rafael Maldonado, Luis Stinus, George F. Koob
    Pages 77-124

  7. Tolerance and Sensitization to Opiates: Relationship to Withdrawal

    • Rafael Maldonado, Luis Stinus, George F. Koob
    Pages 125-152

  8. Treatment of Opiate Withdrawal

    • Rafael Maldonado, Luis Stinus, George F. Koob
    Pages 153-179

  9. The Role of Opiate Withdrawal in Addiction

    • Rafael Maldonado, Luis Stinus, George F. Koob
    Pages 181-198

  10. Back Matter

    Pages 199-204
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Keywords

About this book

Some general aspects of opiate dependence are described in a first section including a brief historical description and an explanation of the different models currently used to investigate opiate dependence. The neurobiological bases of opiate withdrawal are detailed in a second section, which particularly emphasizes the neurophysiological adaptative changes, the processes of homologous and heterologous regulation, and the role played by different brain structures and several endogenous peptides acting as antiopiates. The last part reports several basic aspects more directly related to the clinical perspectives of opiate dependence, such as the new expectations in the treatment of opiate withdrawal or the relationships between sensitization, tolerance and withdrawal.

Authors and Affiliations

  • Pharmacochimie Moléculaire et Structurale, Paris, France

    Rafael Maldonado

  • Université de Bordeaux II, Bordeaux Cédex, France

    Luis Stinus

  • The Scripps Research Institute, La Jolla, USA

    George F. Koob

Bibliographic Information

  • Book Title: Neurobiological Mechanisms of Opiate Withdrawal

  • Authors: Rafael Maldonado, Luis Stinus, George F. Koob

  • Series Title: Neuroscience Intelligence Unit

  • DOI: https://doi.org/10.1007/978-3-662-22218-8

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1996

  • Softcover ISBN: 978-3-662-22220-1Published: 19 November 2013

  • eBook ISBN: 978-3-662-22218-8Published: 11 November 2013

  • Series ISSN: 1431-0406

  • Edition Number: 1

  • Number of Pages: XI, 204

  • Number of Illustrations: 3 b/w illustrations

  • Additional Information: Jointly published with R.G. Landes, Biomedical Publishers, Georgetown, USA

  • Topics: Neurosciences, Pharmacology/Toxicology

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