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Neural Transplantation in Cerebellar Ataxia

  • Book
  • © 1997

Overview

Authors:
  1. Lazaros C. Triarhou

    1. Indiana University School of Medicine, Indianapolis, USA

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Part of the book series: Neuroscience Intelligence Unit (NIU.LANDES)

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Table of contents (9 chapters)

  1. Front Matter

    Pages i-ix
    Download chapter PDF

  2. Introduction

    • Lazaros C. Triarhou
    Pages 1-3

  3. Cerebellar Structure and Development

    • Lazaros C. Triarhou
    Pages 5-29

  4. The Human Cerebellar Ataxias

    • Lazaros C. Triarhou
    Pages 31-43

  5. Cerebellar Mutants in the Laboratory Mouse

    • Lazaros C. Triarhou
    Pages 45-79

  6. Neurological Mutant Mice as Genetic Models for Neuronal Transplantation

    • Lazaros C. Triarhou
    Pages 81-94

  7. Basic Studies on Cerebellar Tissue Transplantation

    • Lazaros C. Triarhou
    Pages 95-112

  8. Structural Integration of Cerebellar Grafts in Ataxic Mouse Mutants

    • Lazaros C. Triarhou
    Pages 113-129

  9. Cerebellar Grafting and the Recovery of Function

    • Lazaros C. Triarhou
    Pages 131-148

  10. Clinical Potential

    • Lazaros C. Triarhou
    Pages 149-158

  11. Back Matter

    Pages 159-162
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Keywords

About this book

erebellar ataxia is a failure in muscular coordination that re­ C sults from a slow, progressive deterioration of neurons in the cerebellum. An estimated 150,000 people are affected by the he­ reditary ataxias and related disorders in the United States. At present, there is no known cure. In an experimental treatment aimed at reconstructing the damaged pathway through exog­ enous neuronal supplementation, genetically ataxic mice have been used for intracerebral grafting of genetically healthy cerebellar neuroblasts, and evidence has been obtained for graft-induced en­ hancement of behavioral responses after bilateral cerebellar grafts. Such results are encouraging and underscore the potential of the neural grafting technique in restoring cerebellar function. How­ ever, many of the pathological and biochemical mechanisms in the interaction between grafted tissue and the host brain need to be further elucidated in extensive experimental studies, and great cau­ tion must be used in contemplating the theoretical feasibility of a possible application in humans.

Authors and Affiliations

  • Indiana University School of Medicine, Indianapolis, USA

    Lazaros C. Triarhou

Bibliographic Information

  • Book Title: Neural Transplantation in Cerebellar Ataxia

  • Authors: Lazaros C. Triarhou

  • Series Title: Neuroscience Intelligence Unit

  • DOI: https://doi.org/10.1007/978-3-662-22213-3

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1997

  • Softcover ISBN: 978-3-662-22215-7Published: 20 November 2013

  • eBook ISBN: 978-3-662-22213-3Published: 11 November 2013

  • Series ISSN: 1431-0406

  • Edition Number: 1

  • Number of Pages: IX, 162

  • Number of Illustrations: 39 b/w illustrations, 1 illustrations in colour

  • Additional Information: Jointly published with R.G. Landes, Biomedical Publishers, Georgetown, USA

  • Topics: Neurosciences

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