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Long Circulating Liposomes: Old Drugs, New Therapeutics

  • Book
  • © 1998

Overview

Editors:
  1. Martin C. Woodle

    1. Genetic Therapy, Inc., Gaithersburg, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Gerrit Storm

    1. Department of Pharmaceutics, University of Utrecht, Utrecht, The Netherlands

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Biotechnology Intelligence Unit (BIOIU)

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-xx
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  2. Introduction

    1. Front Matter

      Pages 1-1
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    2. Long Circulating Liposome Therapeutics: From Concept to Clinical Reality

      • Gerrit Storm, Martin C. Woodle
      Pages 3-16

  3. Current Medical Applications

    1. Front Matter

      Pages 17-17
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    2. Malignant Diseases

      1. Oncologic Agents in Sterically Stabilized Liposomes: Basic Considerations
        • Theresa M. Allen
        Pages 19-28
      2. Liposomal Vincristine: The Central Role of Drug Retention in Defining Therapeutically Optimized Anticancer Formulations
        • Nancy L. Boman, Pieter R. Cullis, Lawrence D. Mayer, Marcel B. Bally, Murray S. Webb
        Pages 29-49
      3. Long Circulating Liposome-Encapsulated Tumor Necrosis Factor in the Treatment of Solid Tumors
        • Timo L. M. ten Hagen, Alexander H. van der Veen, Alexander M. M. Eggermont
        Pages 51-60
      4. Therapy of Human Carcinoma Xenografts with Doxorubicin Encapsulated in Sterically Stabilized Liposomes (DOXIL®): Efficacy and Safety Studies
        • Jan Vaage, Paul S. Uster, Peter K. Working
        Pages 61-72
      5. Design and Development of Long Circulating Liposomal Daunorubicin for In Vivo Targeting of Solid Tumors: DaunoXome®
        • Eric A. Forssen, Richard T. Proffitt
        Pages 73-96
      6. Enhancement of Doxorubicin by Encapsulation in Long Circulating Thermosensitive Liposomes Combined with Local Hyperthermia
        • Kazuo Maruyama
        Pages 97-109
      7. Liposomal Localization and Chemotherapy for AIDS-Related Kaposi’s Sarcoma
        • Mark Harrison, K. J. Harrington, J. S. W. Stewart
        Pages 111-125
      8. Pegylated-Liposomal Doxorubicin (Doxil®) in the Treatment of AIDS-Related Kaposi’s Sarcoma
        • Donald W. Northfelt
        Pages 127-145
      9. DaunoXome® (Liposomal Daunorubicin) for First-Line Treatment of Advanced, HIV-Related Kaposi’s Sarcoma
        • Geoffrey Mukwaya, Eric A. Forssen, Paul Schmidt, Michael Ross
        Pages 147-163
      10. Initial Clinical Evaluation of Pegylated-Liposomal Doxorubicin in Solid Tumors
        • Alberto A. Gabizon, Franco M. Muggia
        Pages 165-174

    3. Other Therapeutic Applications

      1. Antibacterial Therapy with Sterically Stabilized Liposome Formulations
        • Irma A. J. M. Bakker-Woudenberg, Gerrit Storm, Martin C. Woodle
        Pages 177-183
      2. AmBisome®: Long Circulating Liposomal Formulation of Amphotericin B
        • Jill P. Adler-Moore, Richard T. Proffitt
        Pages 185-206
      3. Steric Stabilization of Liposomes Containing Amphotericin B: A Future Direction in Antifungal Therapy?
        • Els W. M. van Etten, Irma A. J. M. Bakker
        Pages 207-211
      4. Clinical and Preclinical Studies with Low-Clearance Liposomal Amikacin (MiKasome®)
        • Robert M. Fielding, Geoffrey Mukwaya, Robert A. Sandhaus
        Pages 213-225

    4. Diagnostics

      1. Sterically Stabilized Liposomes to Image Infection and Inflammation
        • Otto C. Boerman, Wim J. G. Oyen, Frans H. M. Corstens, Gerrit Storm
        Pages 229-240
      2. Long Circulating Liposomes for Diagnostic Imaging
        • Vladimir S. Trubetskoy, Vladimir P. Torchilin
        Pages 241-255
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Keywords

About this book

This book provides an up-to-date evaluation of clinical aspects of newly available "long-circulating liposome" formulations. Based on results from numerous clinical studies, the book describes the fundamentals of this new technology, discusses how it may influence the pharmacology of existing well-known agents reformulated in this manner, and elaborates on future expectations. It provides the practicing clinician - in particular, oncologists and critical care infectious disease physicians - with the tools needed to use these new formulations towards the best outcome for the patient.

Editors and Affiliations

  • Genetic Therapy, Inc., Gaithersburg, USA

    Martin C. Woodle

  • Department of Pharmaceutics, University of Utrecht, Utrecht, The Netherlands

    Gerrit Storm

Bibliographic Information

  • Book Title: Long Circulating Liposomes: Old Drugs, New Therapeutics

  • Editors: Martin C. Woodle, Gerrit Storm

  • Series Title: Biotechnology Intelligence Unit

  • DOI: https://doi.org/10.1007/978-3-662-22115-0

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1998

  • Softcover ISBN: 978-3-662-22117-4Published: 13 November 2013

  • eBook ISBN: 978-3-662-22115-0Published: 29 June 2013

  • Edition Number: 1

  • Number of Pages: XX, 301

  • Number of Illustrations: 34 b/w illustrations

  • Additional Information: Jointly published with Landes Bioscience, Georgetown, USA

  • Topics: Cancer Research, Pharmacology/Toxicology, Cell Biology, Molecular Medicine, Biotechnology, Oncology

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