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Local Immunosuppression of Organ Transplants

  • Book
  • © 1996

Overview

Authors:
  1. Scott A. Gruber

    1. Albany Medical College, Albany, USA

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Part of the book series: Medical Intelligence Unit (MIU.LANDES)

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-xv
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  2. Background

    1. Front Matter

      Pages 1-1
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    2. Local Regulation of Allograft Rejection

      • Scott A. Gruber, Shengguang Xiao, Stephen E. Hughes
      Pages 3-11

    3. Pharmacokinetic Advantage of Regional Drug Delivery

      • Stephen E. Hughes, Sardha Perera, Scott A. Gruber
      Pages 13-16

    4. Early Studies of Local Immunosuppression (1964–1984)

      • Stephen E. Hughes, Sardha Perera, Scott A. Gruber
      Pages 17-21

  3. Pump-Based Local Infusion in Rat Allograft Models

    1. Front Matter

      Pages 23-23
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    2. Selective Immunosuppression by Local Treatment of the Allograft

      • T. J. M. Ruers
      Pages 25-38

    3. Local Immunosuppression of Rat Cardiac, Liver, and Small Bowel Allografts

      • Mou-er Wang, Stanislaw M. Stepkowski, Barry D. Kahan
      Pages 39-45

    4. Inhibition of Cardiac Allograft Rejection by Continuous Local Infusion of 16,16 Di-Methyl PGE2

      • M. Wayne Flye, Samuel Yu
      Pages 47-57

    5. Intrarenal Administration of Anti T Cell-Monoclonal Antibody

      • Norio Yoshimura, Chol Joo Lee, Takahiro Oka
      Pages 59-68

    6. Intraportal Delivery of Immunosuppressants to Intrahepatic Islet Allografts

      • Donald C. Dafoe, Edward J. Alfrey
      Pages 69-77

  4. Pump-Based Local Infusion in Canine Allograft Models

    1. Front Matter

      Pages 79-79
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    2. Local Heparin, 6-Mercaptopurine, Prednisolone, and Mizoribine Delivery in a Canine Renal Allograft Model

      • Scott A. Gruber, Shengguang Xiao, Stephen E. Hughes
      Pages 81-96

    3. Intraportal Cyclosporine A in Canine Liver Transplantation

      • Saiho Ko, Yoshiyuki Nakajima, Hiroshige Nakano
      Pages 97-105

  5. Other Drug Targeting Systems for Achieving Local Immunosuppression

    1. Front Matter

      Pages 107-107
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    2. Liposomal Cyclosporine A

      • Chris E. Freise, Nancy L. Ascher, John P. Roberts
      Pages 109-118

    3. Liposomal FK506 in a Canine Hepatic Allograft Model

      • Saiho Ko, Yoshiyuki Nakajima, Hiroshige Nakano
      Pages 119-129

    4. Cyclosporine Aerosol in Lung Transplantation

      • Gilbert J. Burckart, Robert J. Keenan, Aldo T. Iacono, Bartley P. Griffith
      Pages 131-139

    5. Site-Specific Immunosuppression with Topical Agents

      • Kirby S. Black, Charles W. Hewitt
      Pages 141-152

    6. Local Immunosuppression in Corneal Transplantation

      • Ali R. Djalilian, Edward J. Holland
      Pages 153-159
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Keywords

About this book

For the first time a complete review of the research work done over the past 30 years by leading investigators around the world in targeting immunosuppressants to both solid-organ and cellular transplants is available in a single volume. One section consists of studies conducted in rat allograft models using osmotic minipumps for delivery of a variety of immunosuppressants. The book will be of great benefit to researchers in the fields of transplant immunology, pharmacology and drug delivery and targeting, particularly those involved in drug development.

Authors and Affiliations

  • Albany Medical College, Albany, USA

    Scott A. Gruber

Bibliographic Information

  • Book Title: Local Immunosuppression of Organ Transplants

  • Authors: Scott A. Gruber

  • Series Title: Medical Intelligence Unit

  • DOI: https://doi.org/10.1007/978-3-662-22105-1

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1996

  • Softcover ISBN: 978-3-662-22107-5Published: 13 November 2013

  • eBook ISBN: 978-3-662-22105-1Published: 21 November 2013

  • Series ISSN: 1080-3645

  • Edition Number: 1

  • Number of Pages: XV, 217

  • Number of Illustrations: 64 b/w illustrations

  • Additional Information: Jointly published with R.G. Landes, Biomedical Publishers, Austin, USA

  • Topics: Immunology, Pharmacology/Toxicology, Transplant Surgery

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