Liver and Environmental Xenobiotics

1. Front Matter

   Pages i-x

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2. Extracellular Matrix in Liver

   • P. R. Sudhakaran, N. Anil Kumar, Anitha Santhosh

   Pages 1-18

3. Drug Metabolizing Enzymes in the Liver

   • Mohammad Athar, S. Zakir Husain, Nafisul Hasan

   Pages 19-30

4. Liver Injury: Genetic factors in alcohol and acetaldehyde metabolism

   • Mikihiro Tsutsumi, Akira Takada

   Pages 31-39

5. An Enhanced Liver Injury Induced by Carbon Tetrachloride in Acatalasemic Mice

   • Kunihiko Ishii, Da-Hong Wang, Li-Xue Zhen, Masaki Satho, Kazuhisa Taketa

   Pages 40-52

6. Liver Injury in Ischemia and Reperfusion

   • Koji Ito, Junichi Uchino, Yasuaki Nakajima, Jun Kimura

   Pages 53-60

7. Liver Injury and Serum Hyaluronan

   • Takato Ueno, Kyuichi Tanikawa

   Pages 61-71

8. Phthalic Acid Esters and Liver

   • D. Parmar, P. K. Seth

   Pages 72-91

9. Role of Nitric Oxide (NO) in the D-Galactosamine-Induced Liver Injury

   • Hironori Sakai, Hidehiko Isobe, Hajime Nawata

   Pages 92-101

10. Generation of Reactive Oxygen Species, DNA Damage and Lipid Peroxidation in Liver by Structurally Dissimilar Pesticides

    • S. J. Stohs, D. Bagchi, M. Bagchi, E. A. Hassoun

    Pages 102-113

11. Oxidative Stress and Liver Injury by Environmental Xenobiotics

    • S. V. S. Rana

    Pages 114-134

12. Experimental Hepatocarcinogenesis and Its Prevention

    • Kiwamu Okita, Isao Sakaida, Yuko Matsuzaki

    Pages 135-150

13. Oncogene Expression in Liver Injury

    • Yutaka Sasaki, Norio Hayashi, Masayoshi Horimoto, Toshifumi Ito, Hideyuki Fusamoto, Takenobu Kamada

    Pages 151-166

14. Undifferentiated Gene Expression as the Entity of Liver Injuries

    • Kazuhisa Taketa

    Pages 167-177

15. Standard Liver Function Tests and Their Limitations: Selectivity and sensitivity of individual serum bile acid levels in hepatic dysfunction

    • Samy A. Azer, Geoffrey W. McCaughan, Neill H. Stacey

    Pages 178-203

16. Hepatic Bilirubin Metabolism: Physiology and Pathophysiology

    • Yukihiko Adachi, Toshinori Kamisako

    Pages 204-219

17. Hepatotrophic Activities of HGF in Liver Regeneration after Injury and the Clinical Potentiality for Liver Diseases

    • Uichi Koshimizu, Kunio Matsumoto, Toshikazu Nakamura

    Pages 220-229

18. Apoptosis in Liver

    • Akira Ichihara

    Pages 230-235

The general populations are incidentally exposed to a wide variety of xenobiotics as a consequence of the pollution of the environment by industrial and agricultural chemicals. Xenobiotics entering the animal will undergo one or more of the following fate: (a) elimination unchanged, (b) metabolism by enzymes, (c) spontaneous chemical transformation and (d) remain unchanged in the body. The actions of xenobiotics on the body exhibit certain specificity depending upon the compound's chemical structure and reactivity. Since the processes of metabolism change these chemical properties ofaxenobiotic, bewildering number of reactions continue to pose new challenges to toxicologists and pharmacologists. It necessitates periodic and precise revision of the subject. This book contains invited contributions from learned colleagues that offer an excellent survey of and profound insight into the disposition and metabolism of a few environmentally and industrially significant xenobiotics. The topics range from an assessment of drug metabolising enzymes in the liver, DNA damage by reactive oxygen species generated by pesticides, role of NO in liver injury, hepatotrophicgrowth factor in liver regeneration, extracellular matrix in the liver, oncogene expression in liver injury, the hepatocarcinogenesis to oxidative stress and undifferentiated gene expression. Detailed analysis of the validity of liver function tests has been included. Last Chapter addresses the problem of apoptosis, which plays a key role in the signal transduction system of xenobiotics-induced liver injury. The reader should appreciate that overall exposure to this field is expanding at a rapid pace and selections had to be made.

• Stress
• drug
• liver
• metabolism
• oncogene
• pesticide

• Department of Zoology, Ch. Charan Singh University, Meerut, India

  S. V. S. Rana

• Department of Public Health, Okayama University Medical School, Okayama 700, Japan

  K. Taketa

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