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Intrabodies

Basic Research and Clinical Gene Therapy Applications

  • Book
  • © 1998

Overview

Editors:
  1. Wayne A. Marasco

    1. Division of Human Retrovirology, Dana-Farber Cancer Institute, Boston, USA

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  • State-of-the-art resource for gene therapists and all researchers interested in using intrabodies in gene therapy

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-xiv
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  2. Designing Intrabodies: Structural Features and the Use of Intracellular Trafficking Signals

    • Wayne A. Marasco
    Pages 1-22

  3. Phage Libraries for Generation of Single Chain Fv Antibodies for Intracellular Immunization

    • Marie Alix Poul, James D. Marks
    Pages 23-46

  4. Phenotypic Knockout of the Human Interleukin-2 Receptor α Chain on Primary and HTLV-I Transformed T Cells

    • Jennifer H. Richardson, Wayne A. Marasco
    Pages 47-60

  5. Intracellular Antibodies as Tools to Study ErbB Receptor Tyrosine Kinases

    • Roger R. Beerli, Diana Graus-Porta, Nancy E. Hynes
    Pages 61-74

  6. Neuroantibodies: The Use of Recombinant Antibody Expression in the Central Nervous System

    • Antonino Cattaneo, Patrizia Piccioli, Francesca Ruberti
    Pages 75-96

  7. Intracellular Antibody-Mediated Knockout of the ErbB-2 Oncoprotein as a Cancer Gene Therapy Approach

    • David T. Curiel
    Pages 97-128

  8. Intracellular Targeting of Oncogenes: A Novel Approach for Cancer Therapy

    • Olivier Cochet, Isabelle Delumeau, Mireille Kenigsberg, Nadège Gruel, Fabien Schweighoffer, Laurent Bracco et al.
    Pages 129-146

  9. Intrabodies Against the HIV-1 Regulatory Proteins: Tat and Rev as Targets for Gene Therapy

    • Abner M. Mhashilkar, Wayne A. Marasco
    Pages 147-161

  10. Gene Therapy for HIV-1 Using Intracellular Antibodies Against HIV-1 Gag Proteins

    • Isaac J. Rondon, Wayne A. Marasco
    Pages 163-181

  11. Single Chain Variable Fragment-Based Strategies for Anti-HIV-1 Gene Therapy: Targeting the Viral Preintegration Complex and Combination Molecular Approaches

    • Lingxun Duan, Roger J. Pomerantz
    Pages 183-208

  12. Back Matter

    Pages 209-211
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Keywords

Editors and Affiliations

  • Division of Human Retrovirology, Dana-Farber Cancer Institute, Boston, USA

    Wayne A. Marasco

Bibliographic Information

  • Book Title: Intrabodies

  • Book Subtitle: Basic Research and Clinical Gene Therapy Applications

  • Editors: Wayne A. Marasco

  • DOI: https://doi.org/10.1007/978-3-662-12119-1

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1998

  • Softcover ISBN: 978-3-662-12121-4Published: 23 August 2014

  • eBook ISBN: 978-3-662-12119-1Published: 09 March 2013

  • Edition Number: 1

  • Number of Pages: XIV, 211

  • Number of Illustrations: 86 b/w illustrations

  • Additional Information: Jointly published with Landes Bioscience, Georgetown, USA

  • Topics: Molecular Medicine, Human Genetics, Cell Biology, Cancer Research

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