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Gene Therapy for HIV Infection

  • Book
  • © 1998

Overview

Authors:
  1. Clay Smith

    1. Bone Marrow Transplantation Program, Duke University Medical Center, Durham, USA

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  • How to develop effective gene therapy to fight HIV infection.

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Table of contents (8 chapters)

  1. Front Matter

    Pages i-xvii
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  2. Replicative Cycle of HIV

    • Magnús Gottfredsson
    Pages 1-12

  3. Gene Therapy Strategies for Inhibition of HIV

    • Magnús Gottfredsson
    Pages 13-47

  4. Trans-Splicing Ribozymes as Potential HIV Gene Inhibitors

    • Seong-Wook Lee, Bruce A. Sullenger
    Pages 49-58

  5. Viral Vectors for HIV Gene Therapy

    • Kenneth L. Phillips
    Pages 59-75

  6. T Lymphocyte Based HIV Gene Therapy Strategies

    • Tracy Gentry
    Pages 77-94

  7. Stem Cell-Based Gene Therapies in the Treatment of AIDS

    • Robert Storms
    Pages 95-117

  8. Animal Models of Gene Therapy for AIDS

    • Linda M. Kofeldt, David Camerini
    Pages 119-140

  9. Hematopoietic Stem Cell Transplantation and HIV Gene Therapy

    • Clay Smith, Cristina Gasparetto
    Pages 141-176

  10. Back Matter

    Pages 177-178
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Keywords

About this book

ince the early 1980s, the HIV epidemic has been raging within the S 1 United States and around the world. Drug therapy for HIV infection has not been curative, prompting the search for alternative strategies to control HIV infection within infected persons. One potential alterna­ tive to drug therapy is a developing medical technology termed gene therapy. 2 Gene therapy involves introducing genetic elements into popu­ lations of cells in order to correct or prevent a pathologic process. A large number of gene therapy strategies have been developed in an at­ tempt to inhibit HIV expression and spread. These strategies fall into two general categories, genetic modification of cells in order to elicit an immune response against HIV and genetic modification of the target cells of HIV infection in order to block HIV expression and reproduction. In the first strategy, termed genetic immunotherapy by some, genetic material encoding HIV proteins is introduced into patient's cells in order to stimulate a cellular immune response above and beyond 3 5 that stimulated by the viral infection itself. - Two general genetic im­ munotherapy strategies have been developed. Genes encoding HIV pro­ teins have been directly injected into the dermis or muscle tissue of patients. These genes have been encoded in plasmids or viral DNA and have been injected either in the form of naked DNA or complexed with lipids.

Authors and Affiliations

  • Bone Marrow Transplantation Program, Duke University Medical Center, Durham, USA

    Clay Smith

Bibliographic Information

  • Book Title: Gene Therapy for HIV Infection

  • Authors: Clay Smith

  • DOI: https://doi.org/10.1007/978-3-662-11821-4

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1998

  • Softcover ISBN: 978-3-662-11823-8Published: 06 January 2013

  • eBook ISBN: 978-3-662-11821-4Published: 09 March 2013

  • Edition Number: 1

  • Number of Pages: XVII, 178

  • Number of Illustrations: 27 b/w illustrations

  • Additional Information: Jointly published with Landes Bioscience, Georgetown, USA

  • Topics: Immunology, Molecular Medicine, Allergology

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