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Cardiac Energetics

Basic Mechanisms and Clinical Implications

  • Conference proceedings
  • © 1987

Overview

Editors:
  1. R. Jacob
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  2. Hj. Just
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  3. Ch. Holubarsch
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Table of contents (40 papers)

  1. Front Matter

    Pages I-IX
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  2. Cardiac energetics as related to basic mechanisms and mechanical conditions

    1. Front Matter

      Pages 1-1
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    2. The mechanism of muscle contraction. Biochemical, mechanical, and structural approaches to elucidate cross-bridge action in muscle

      • B. Brenner, E. Eisenberg
      Pages 3-16

    3. Energetics studies of muscles of different types

      • M. J. Kushmerick
      Pages 17-30

    4. High energy phosphate of the myocardium: Concentration versus free energy change

      • H. Kammermeier
      Pages 31-36

    5. Cardiac basal and activation metabolism

      • D. S. Loiselle
      Pages 37-50

    6. Mechanical determinants of myocardial energy turnover

      • G. Elzinga, C. M. B. Duwel, F. Mast, N. Westerhof
      Pages 51-59

    7. Cardiac energetics and the Fenn effect

      • C. L. Gibbs
      Pages 61-68

    8. Cardiac energetics: significance of mitochondria

      • M. Siess
      Pages 69-83

    9. Heat production and oxygen consumption following contraction of isolated rabbit papillary muscle at 20 °C

      • F. Mast, G. Elzinga
      Pages 85-92

    10. Regulation of heart creatine kinase

      • J. S. Ingwall, J. A. Bittl
      Pages 93-101

    11. Effect of creatine depletion on myocardial mechanics

      • B. Korecky, Y. Brandejs-Barry
      Pages 103-110

    12. ATPase activity of intact single muscle fibres of Xenopus laevis is related to the rate of force redevelopment after rapid shortening

      • G. J. M. Stienen, J. Lännergren, G. Elzinga
      Pages 111-117

  3. Cardiac energetics as related to ontogenesis, chronic myocardial transformation and inotropic interventions

    1. Front Matter

      Pages 119-119
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    2. Developmental differences in myocardial ATP metabolism

      • J. W. de Jong, P. W. Achterberg
      Pages 121-126

    3. The effects of acute and chronic inotropic interventions on tension independent heat of rabbit papillary muscle

      • E. M. Blanchard, L. A. Mulieri, Norman R. Alpert
      Pages 127-135

    4. Chronic cardiac reactions. I. Assessment of ventricular and myocardial work capacity in the hypertrophied and dilated ventricle

      • R. Jacob, M. Vogt, K. Noma
      Pages 137-145

    5. Chronic cardiac reactions. II. Mechanical and energetic consequences of myocardial transformation versus ventricular dilatation in the chronically pressure-loaded heart

      • M. Vogt, R. Jacob, G. Kissling, H. Rupp
      Pages 147-159

    6. Chronic cardiac reactions. III. Factors involved in the development of structural dilatation

      • M. Vogt, R. Jacob, K. Noma, B. Onegi, H. Rupp
      Pages 161-172

    7. Chronic cardiac reactions. IV. Effect of drugs and altered functional loads on cardiac energetics as inferred from myofibrillar ATPase and the myosin isoenzyme population

      • Heinz Rupp, R. Wahl, R. Jacob
      Pages 173-182
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Keywords

About this book

Assessment of cardiac energetics at the level of ATP-synthesis, chemomechanical energy transformation and whole organ dynamics as a function of haemodynamic load, ventricular configuration and oxygen- and substrates supply is basic to understanding cardiac function under physiological and pathophysiological (hypertrophy, hypoxia, ischaemia and heart failure) conditions. Moreover, cardiac energetics should be an important consideration in the choice and application of drugs especially in the case of vasodilators, inotropic agents and in cardioprotective measures. Only by considering energetics at the subcellular, cellular, and whole-heart level we can arrive at a better understanding of cardiac performance and ultimately better clinical judgement and drug therapy. Quantification of myocardial energetics will also help to determine the optimal time for surgical interventions such as valvular replacement or aneurysm resection. The present volume is the outcome of an international symposium on cardiac energetics held in Gargellen/Montafon (Austria), June 1986. The contributions will certainly help bridge the existing gap between basic research involving isolated structures and that involving the whole organ, on the one hand, and render the results derived from basic research applicable to clinical problems, on the other hand.

Bibliographic Information

  • Book Title: Cardiac Energetics

  • Book Subtitle: Basic Mechanisms and Clinical Implications

  • Editors: R. Jacob, Hj. Just, Ch. Holubarsch

  • DOI: https://doi.org/10.1007/978-3-662-11289-2

  • Publisher: Steinkopff Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1987

  • Softcover ISBN: 978-3-662-11291-5Published: 03 October 2013

  • eBook ISBN: 978-3-662-11289-2Published: 17 April 2013

  • Edition Number: 1

  • Number of Pages: IX, 425

  • Number of Illustrations: 50 b/w illustrations

  • Additional Information: Jointly published with Springer-Verlag New York: ISBN 0-387-91294-0

  • Topics: Cardiology, Human Physiology

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