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The Mechanisms of Neuronal Damage in Virus Infections of the Nervous System

  • Book
  • © 2001

Overview

Editors:
  1. Georg Gosztonyi

    1. Universitätsklinikum Benjamin Franklin Abt. für Neuropathologie, FU Berlin, Fachbereich Humanmedizin, Berlin, Germany

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Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 253)

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Table of contents (12 chapters)

  1. Front Matter

    Pages I-IX
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  2. The Concept of Neurotropism and Selective Vulnerability (“Pathoclisis”) in Virus Infections of the Nervous System — A Historical Overview

    • G. Gosztonyi, H. Koprowski
    Pages 1-13

  3. The Mechanisms of Direct, Virus-Induced Destruction of Neurons

    • J. R. Anderson
    Pages 15-33

  4. Slow and Persistent Virus Infections of Neurones — A Compromise for Neuronal Survival

    • U. G. Liebert
    Pages 35-60

  5. Neuronal Latency in Human and Animal Herpesvirus Infections

    • K. Borchers, H. J. Field
    Pages 61-94

  6. Programmed Cell Death in Virus Infections of the Nervous System

    • J. K. Fazakerley, T. E. Allsopp
    Pages 95-119

  7. Interactions of Viral Proteins with Neurotransmitter Receptors May Protect or Destroy Neurons

    • G. Gosztonyi, H. Ludwig
    Pages 121-144

  8. Mechanisms of Virus-Induced Neuronal Damage and the Clearance of Viruses from the CNS

    • B. Dietzschold, K. Morimoto, D. C. Hooper
    Pages 145-155

  9. Borna Disease Virus Infection of Adult and Neonatal Rats: Models for Neuropsychiatric Disease

    • M. Hornig, M. Solbrig, N. Horscroft, H. Weissenböck, W. I. Lipkin
    Pages 157-177

  10. The Mechanisms of Neuronal Damage in Retroviral Infections of the Nervous System

    • V. J. Sanders, C. A. Wiley, R. L. Hamilton
    Pages 179-201

  11. Prion-Induced Neuronal Damage — The Mechanisms of Neuronal Destruction in the Subacute Spongiform Encephalopathies

    • A. Giese, H. A. Kretzschmar
    Pages 203-217

  12. The Role of T-Cell-Mediated Mechanisms in Virus Infections of the Nervous System

    • R. Dörries
    Pages 219-245

  13. Virus-Induced Autoimmune Reactions in the CNS

    • P. J. Talbot, D. Arnold, J. P. Antel
    Pages 247-271

  14. Back Matter

    Pages 273-280
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Keywords

About this book

It has been recognized that viruses can induce neuronal damage by a variety of mechanisms. This volume summarizes, for the first time, the various ways that neurons can degenerate under the influence of viral infection, ranging from acute necrosis and virus-induced apoptosis to chronic damage in persistent infections. The mechanisms of neuronal latency are dealt with as well. The volume also includes chapters that review the chronic damage caused by viral proteins that interfere with differentiated functions of the neuron, including signaling by neurotransmitters and signal transduction by trophic factors. Other chapters deal with the controversial role of cellular immune reactions, which may be helpful in controlling infection, but may also be detrimental to the host nervous system. The specific mechanisms of damage involved in retroviral infections and in prion diseases of the nervous system are reviewed, and finally how autoimmune diseases can lead to neuronal damage.

Editors and Affiliations

  • Universitätsklinikum Benjamin Franklin Abt. für Neuropathologie, FU Berlin, Fachbereich Humanmedizin, Berlin, Germany

    Georg Gosztonyi

Bibliographic Information

  • Book Title: The Mechanisms of Neuronal Damage in Virus Infections of the Nervous System

  • Editors: Georg Gosztonyi

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-662-10356-2

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2001

  • Hardcover ISBN: 978-3-540-67617-1Published: 24 April 2001

  • Softcover ISBN: 978-3-642-08710-3Published: 05 December 2010

  • eBook ISBN: 978-3-662-10356-2Published: 17 April 2013

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: IX, 280

  • Topics: Immunology, Virology, Neurosciences

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