The Endometrium as a Target for Contraception

1. Front Matter

   Pages I-XV

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2. The Molecular Biology of Progesterone Receptors: Why Are There Two Isoforms?

   • K. B. Horwitz, L. Tung, G. S. Takimoto

   Pages 1-20

3. Hormonal Regulation of the Paracrine Growth Factors HGF and KGF in the Endometrium of the Rhesus Macaque

   • R. M. Brenner, O. D. Slayden, T. Koji, S. Izumi, M. Chedid, K. G. Csaky et al.

   Pages 21-49

4. Cell Biological Aspects of the Implantation Window

   • H. M. Beier

   Pages 51-90

5. The Immune System Acting in the Human Endometrium

   • Y. W. Loke, A. King

   Pages 91-101

6. Cytokines and Their Receptors in the Peri-implantation Endometrium

   • M. J. K. Harper

   Pages 103-122

7. Metalloproteinases and Regulation of Endometrial Function

   • P. Bischof

   Pages 123-136

8. Novel Cell Adhesion Molecules: Roles in Implantation?

   • C. D. MacCalman, A. Omigbodun, X. C. Tian, J. E. Fortune, E. E. Furth, C. Coutifaris et al.

   Pages 137-157

9. The Glycoprotein MUC1 and Extracellular Matrix Molecules as Markers of Endometrial Differentiation

   • J. D. Aplin

   Pages 159-175

10. Intrinsic and Extrinsic Hormonal Influences Contributing to Endometrial Receptivity in Normal Reproduction and After Ovum Donation

    • D. de Ziegler

    Pages 177-191

11. Clinical Significance of Integrin Cell Adhesion Molecules as Markers of Endometrial Receptivity

    • B. A. Lessey, A. J. Castelbaum, S. G. Somkuti, L. Yuan, K. Chwalisz

    Pages 193-221

12. Endometrial Contraception with Progesterone Antagonists: An Experimental Approach

    • K. Chwalisz, I. Gemperlein, C. P. Puri, S. Shao-Qing, R. Knauthe

    Pages 223-258

13. Clinical Strategies for the Achievement of Endometrial Contraception with Progesterone Antagonists

    • H. B. Croxatto, B. Fuentealba, A. M. Salvatierra, R. Massai

    Pages 259-278

14. Back Matter

    Pages 279-284

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This book is a summary of the present state of the art in the physiology of both endometrial receptivity and implantation. Although these physiological processes are today considered as limiting factors responsible for both infertility and low gestation rates in patients undergoing assisted reproductive techniques, they may, on the other hand, represent future targets for contraception. Several aspects of endometrial receptivity and implantation are discussed in this book. In the first part, basic aspects of the cell biology of endometrial functions as well as the molecular aspects of endometrial receptivity and implantation are discussed. Subsequently the clinical and experimental approaches to endometrial contraception are considered. Finally, some basic questions are raised pointing to the need for further research in order to gain a better understanding of the implantation process and the development of new contraceptive strategies, including the inhibition of endometrial receptivity. The organizers of the workshop and the editors of the volume hope that this book will encourage both universities and the pharmaceutical industry to initiate and/or continue research on endometrial receptivity and implantation.

• Cytokines
• Endometrium
• Uterine Physiology
• contraception
• embryo
• fertility
• infertility
• regulation
• reproduction
• reproductive biology

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