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Purinergic and Pyrimidinergic Signalling

Molecular, Nervous and Urogenitary System Function

  • Book
  • © 2001

Overview

Editors:
  1. Maria Pia Abbracchio

    1. Institute of Pharmacological Sciences, University of Milan, Milan, Italy

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    You can also search for this editor in PubMed   Google Scholar

  2. Michael Williams

    1. Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, USA

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    You can also search for this editor in PubMed   Google Scholar

  • This two-part volume is an update and objective state of the art of the current knowledge in the field, with particular emphasis on the development of novel therapeutic entities that may prove useful in several diseases by targeting the purinergic/pyrimidinergic system

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 151 / 1)

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Table of contents (15 chapters)

  1. Front Matter

    Pages I-XXX
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  2. Purinergic Neurotransmission: An Historical Background

    1. Purinergic Neurotransmission: An Historical Background

      • M. P. Abbracchio, M. Williams
      Pages 1-16

  3. Receptor Classification

    1. Front Matter

      Pages 17-17
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    2. P1 Receptors

      • A. Lorenzen, U. Schwabe
      Pages 19-45

    3. P2X Receptors

      • I. P. Chessell, A. D. Michel, P. P. A. Humphrey
      Pages 47-63

    4. P2Y Receptors: Structure and Function

      • M. R. Boarder, T. E. Webb
      Pages 65-88

    5. Purinergic Signalling in Development

      • G. Burnstock
      Pages 89-127

    6. P1 and P2 Purine and Pyrimidine Receptor Ligands

      • K. A. Jacobson, L. J. S. Knutsen
      Pages 129-175

  4. Neurotransmission

    1. Front Matter

      Pages 177-177
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    2. Regulation of Purine Release

      • B. Sperlágh, E. S. Vizi
      Pages 179-208

    3. Ecto-Nucleotidases

      • H. Zimmermann
      Pages 209-250

    4. Role of Purines and Pyrimidines in the Central Nervous System

      • S. A. Masino, T. V. Dunwiddie
      Pages 251-288

    5. The Role of Purines in the Peripheral Nervous System

      • C. Kennedy
      Pages 289-304

    6. Trophic Roles of Purines and Pyrimidines

      • J. T. Neary, M. P. Abbracchio
      Pages 305-338

    7. Nucleoside and Nucleotide Transmission in Sensory Systems

      • G. D. Housley
      Pages 339-369

    8. Roles of Purines in Nociception and Pain

      • M. W. Salter, A. Sollevi
      Pages 371-401

    9. Uridine and Pyrimidine Nucleotides in Cell Function

      • G. P. Connolly
      Pages 403-421

    10. Purinergic Signalling in Lower Urinary Tract

      • G. Burnstock
      Pages 423-515

  5. Back Matter

    Pages 517-526
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Keywords

About this book

Physiological, pharmacological and molecular biological data generated over the past three decades have demonstrated the existence of two major families of extracellular receptors, the P1, a family of four G-protein coupled receptors and the P2, a family of at least 12 receptors responsive to purine (ATP, ADP) and pyrimidine (UTP) nucleotides through which adenosine and ATP can function as extracellular messengers. The present two-part volume represents an integrated compendium of invited chapters by leading researchers in the area focusing on advances in the understanding of purinergic and pyrimidinergic signaling systems, their role(s) in tissue function and pathophysiology and advances in developing potential new medications based on the modulation of P1 and P2 receptor signaling processes. The volumes will thus provide the reader with a topical, comprehensive and integrated overview of this important area.

Editors and Affiliations

  • Institute of Pharmacological Sciences, University of Milan, Milan, Italy

    Maria Pia Abbracchio

  • Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, USA

    Michael Williams

Bibliographic Information

  • Book Title: Purinergic and Pyrimidinergic Signalling

  • Book Subtitle: Molecular, Nervous and Urogenitary System Function

  • Editors: Maria Pia Abbracchio, Michael Williams

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-662-09604-8

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2001

  • Hardcover ISBN: 978-3-540-67849-6Published: 12 February 2001

  • Softcover ISBN: 978-3-642-08742-4Published: 01 December 2010

  • eBook ISBN: 978-3-662-09604-8Published: 29 June 2013

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: XXX, 526

  • Number of Illustrations: 31 b/w illustrations

  • Topics: Pharmacology/Toxicology, Human Physiology, Neurology, Immunology, Endocrinology, Cell Biology

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