Physiology and Pharmacology of Biological Rhythms

1. Front Matter

   Pages I-XXIV

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2. The Vertebrate Clock: Localisation, Connection and Entrainment

   • M. H. Hastings

   Pages 1-28

3. Regulation of Cell Division Cycles by Circadian Oscillators: Signal Transduction Between Clocks

   • L. N. Edmunds Jr.

   Pages 29-53

4. Genetics and Molecular Biology of Circadian Clocks

   • L. Rensing

   Pages 55-77

5. Chemical Neuroanatomy of the Mammalian Circadian System

   • R. Y. Moore

   Pages 79-93

6. Chronobiology of Development and Aging

   • E. Haus, Y. Touitou

   Pages 95-134

7. Rhythms in Second Messenger Mechanisms

   • K. Witte, B. Lemmer

   Pages 135-156

8. 5-Hydroxytryptamine and Noradrenaline Synthesis, Release and Metabolism in the Central Nervous System: Circadian Rhythms and Control Mechanisms

   • K. F. Martin, P. H. Redfern

   Pages 157-176

9. Rhythms in Pharmacokinetics: Absorption, Distribution, Metabolism, and Excretion

   • P. M. Bélanger, B. Bruguerolle, G. Labrecque

   Pages 177-204

10. Progress in the Chronotherapy of Nocturnal Asthma

    • M. H. Smolensky, G. E. D’Alonzo

    Pages 205-249

11. Chronopharmacology of Cardiovascular Diseases

    • B. Lemmer, F. Portaluppi

    Pages 251-297

12. Chronopharmacology of Anticancer Agents

    • F. Lévi

    Pages 299-331

13. The Endocrine System and Diabetes

    • L. Mejean, A. Stricker-Krongrad, A. Lluch

    Pages 333-350

14. Gastrointestinal Tract

    • J. G. Moore, H. Merki

    Pages 351-373

15. The Pineal Gland, Circadian Rhythms and Photoperiodism

    • J. Arendt

    Pages 375-414

16. Problems in Interpreting the Effects of Drugs on Circadian Rhythms

    • N. Mrosovsky

    Pages 415-434

17. Rhythms in Retinal Mechanisms

    • G. D. Block, S. Michel

    Pages 435-455

18. Circadian Rhythms and Depression: Clinical and Experimental Models

    • A. M. Rosenwasser, A. Wirz-Justice

    Pages 457-486

19. Chronobiology and Chronopharmacology of the Haemopoietic System

    • R. Smaaland

    Pages 487-532

20. Chronobiology of the Haemostatic System

    • F. Andreotti, G. Patti

    Pages 533-555

Measured by any criteria, research in chronobiology in general and chronopharmacology in particular has expanded rapidly in recent years. This expansion has been paralleled by an increasing recognition by those outside the field of the relevance and significance of recent developments in chronobiology. Advances in two areas have been chiefly responsible. First, application of the full range of modern techniques in behavioral, neurochemical, and molecular biology have greatly improved our understanding of basic clock mechanisms. In several species the genetic basis of the circadian clock is being progressively delineated. A complete picture of the neurochemical and neuroanatomical structure of the mammalian clock is emerging and the complex pattern of control mechanisms involving endogenous clock mechan­ isms and photic and nonphotic zeitgebers is being built up as a result of behavioral studies. Secondly, in parallel with these exciting developments in basic science, clinical applications are being convincingly demonstrated in the general fields of pharmacology and medicine as well as in specific areas, e.g., jet lag, shiftwork maladaption syndrome, blindness, and cardiovascular system. It is therefore an opportune time to review progress in the field of chronopharmacology and to introduce some of the exciting developments and prospects to a readership beyond the confines of the chronobiological cognoscenti. This volume is therefore aimed primarily at the pharmacologist - whether basic, applied, or clinical-who is not a specialist in chronobiology.

• Asthma
• Biorhythmus
• Chronopharmakologie
• Nervous System
• anatomy
• biological clocks
• biological rhythms
• chronopharmacology
• chronotherapeutics
• circadian rhythms
• metabolism
• physiology

"...a milestone in the development of chronophysiology and chronopharmacology...This outstanding publication is recommended to pharmacologists and chronobiologists, whether basic, applied, or clinical." Chronobiology International

• School of Pharmacy and Pharmacology, University of Bath, Bath, UK

  Peter H. Redfern

• Instituts für Pharmakologie und Toxikologie Fakultät für klinische Medizin Mannheim, Universität Heidelberg, Mannheim, Germany

  B. Lemmer

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