Parasite Antigens in Protection, Diagnosis and Escape

1. Front Matter

   Pages I-X

   PDF

2. Introduction

   • R. J. Terry

   Pages 1-6

3. The Eimeria

   • M. E. Rose

   Pages 7-17

4. Entamoeba Histolytica, Antigens and Amoebiasis

   • A. Chayen, B. Avron

   Pages 19-41

5. Parasite Antigens, Their Role in Protection, Diagnosis and Escape: The Leishmaniases

   • J. Alexander, D. G. Russell

   Pages 43-67

6. Parasite Antigens in Protection, Diagnosis and Escape: Plasmodium

   • C. I. Newbold

   Pages 69-104

7. Toxoplasmosis: The Need for Improved Diagnostic Techniques and Accurate Risk Assessment

   • H. P. A. Hughes

   Pages 105-139

8. Antigens of African Trypanosomes

   • M. J. Turner

   Pages 141-158

9. Antigens of Taeniid Cestodes in Protection, Diagnosis and Escape

   • L. J. S. Harrison, R. M. E. Parkhouse

   Pages 159-172

10. Nematode Antigens

    • N. M. Almond, R. M. E. Parkhouse

    Pages 173-203

11. Schistosomes: Surface, Egg and Circulating Antigens

    • A. J. G. Simpson, S. R. Smithers

    Pages 205-239

12. Trematodes, Excluding Schistosomes with Special Emphasis on Fasciola

    • D. L. Hughes

    Pages 241-260

An estimated 2-3 billion people in the less developed countries suffer from infections, often multiple, caused by a variety of parasitic organisms. These infections are frequently debilitat­ ing rather than fatal, and the toll in human misery is fearsome. To this may be added the prevalence of similar diseases in do­ mestic animals, which diminish supplies of animal pro tein. As the world population increases, the already enormous problem also continues to grow. The resources of the less developed nations are inadequate for solving the problem, and in the de­ veloped countries a lack of interest in tropical diseases has meant low priority for research. Two recent methodological advances now raise the real possibility of a systematic and effec­ tive attack upon these diseases - hybridoma and recombinant nucleic acid technologies. The combination ofthese with the still necessary clinical, parasitological and imrnunological in­ formation permits a logical, planned and realistic approach to diagnosis and treatment. The central aim ofthese modem tech­ niques is to define antigens with regard to diagnosis, protection and pathology. In the case of some diseases, work has already commenced along these lines; in the case of others, knowledge lags a long way behind. This volume represents a summary of current knowledge about a wide, representative spectrum of tropical diseases. There is considerable common ground between the different infections as regards objectives and the methods for achieving them.

• Antigen
• Antigens
• diseases
• infection
• infections
• parasite
• pathology

• National Institute for Medical Research, London, UK

  R. M. E. Parkhouse

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