Novel Approaches to Treatment of Osteoporosis

1. Front Matter

   Pages I-XIII

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2. The Advantages and Limitations of Cell Culture as a Model of Bone Formation

   • K. Dobson, S. Jones, P. Liu, D. Miao, L. Reading, C. Shui et al.

   Pages 1-42

3. The Identification and Isolation of Cells of the Osteoblast Lineage in Cultures of Adult Human Bone-Derived Cells by Dual Labeling with the Monoclonal Antibodies STRO-1 and B4-78

   • K. Stewart, C. Jefferiss, J. Screen, S. Walsh, J. N. Beresford

   Pages 43-59

4. Apoptosis in Bone Cells

   • B. F. Boyce, D. E. Hughes, K. R. Wright, L. Xing, A. Dai

   Pages 61-82

5. Genetics in Osteoporosis

   • B. L. Langdahl, E. F. Eriksen

   Pages 83-101

6. The Regulation of Bone Cell Differentiation and Proliferation by Transcription Factors

   • A. E. Grigoriadis, A. Sunters

   Pages 103-121

7. Transgenic and Gene Knock-Out Animals in Skeletal Research

   • M. Amling, M. W. Hentz, M. Priemel, G. Delling

   Pages 123-155

8. Mechanotransduction: An Inevitable Process for Skeletal Maintenance

   • C. H. Turner, R. L. Duncan, F. M. Pavalko

   Pages 157-177

9. The Regulation of Gene Expression in Bone by Mechanical Loading

   • T. M. Skerry

   Pages 179-198

10. Amplification of the Osteogenic Stimulus of Load-Bearing as a Logical Therapy for the Treatment and Prevention of Osteoporosis

    • L. E. Lanyon

    Pages 199-209

11. Novel Aspects of Parathyroid Hormone/Parathyroid Hormone-Related Protein Hormone-Receptor Interactions

    • L. J. Suva

    Pages 211-225

12. Bone Morphogenetic Proteins: Role, Modes of Action and Potential Significance in Osteoporosis

    • P. J. Marie

    Pages 227-260

13. Back Matter

    Pages 261-264

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Osteoporosis affects a growing number of the population. Current treatments are based on prevention of further bone loss after the condition is diagnosed, often because a fracture has occurred. Treatments in the future will aim at healing osteoporosis by improving bone mass and quality. This book describes novel discoveries and research which will allow bone to be restored after it has been lost.

• Monoclonal Antibodies
• antibody
• apoptosis
• biology
• cell
• cell culture
• cell differentiation
• gene
• gene expression
• genetics
• molecular biology
• protein
• regulation
• research
• transcription

• Human Metabolism and Clinical Biochemistry, Sheffield University Medical School, Sheffield, UK

  R. Graham G. Russell

• Department of Biology, University of York, York, UK

  Timothy M. Skerry

• FC/HT Research, Schering AG, Berlin, Germany

  Uwe Kollenkirchen

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