Mechanisms in Carcinogenesis and Cancer Prevention

1. Front Matter

   Pages I-XXI

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2. Causes of Cancer and Opportunities for Prevention

   • H. Vainio, E. Hietanen

   Pages 1-11

3. Genetic and Environmental Factors in Carcinogenesis

   • K. Hemminki

   Pages 13-24

4. Genetic Pathways to Human Cancer

   • H. Ohgaki, W. Yasui, J. Yokota

   Pages 25-39

5. Signalling Pathways as Targets in Cancer Prevention

   • M. M. Manson, L. M. Howells, E. A. Hudson

   Pages 41-56

6. TP53 in Carcinogenesis and Cancer Prevention

   • E. Gormally, P. Hainaut

   Pages 57-81

7. Apoptosis

   • B. W. Stewart

   Pages 83-106

8. Deficient DNA Mismatch Repair in Carcinogenesis

   • P. Peltomäki

   Pages 107-128

9. Epigenetic Changes, Altered DNA Methylation and Cancer

   • F. Lyko

   Pages 129-140

10. Hormonal Carcinogenesis

    • R. Kaaks

    Pages 141-167

11. Angiogenesis: A Promising Target for Cancer Prevention

    • I. U. Ali

    Pages 169-185

12. Arachidonic Acid Pathway in Cancer Prevention

    • G. J. Kelloff, C. C. Sigman

    Pages 187-210

13. Infections, Inflammation and Cancer: Roles of Reactive Oxygen and Nitrogen Species

    • H. Ohshima, M. Tatemichi

    Pages 211-227

14. Infections and the Etiology of Human Cancer: Epidemiological Evidence and Opportunities for Prevention

    • F. X. Bosch, S. de Sanjosé, J. Ribes, C. A. González

    Pages 229-251

15. Xenobiotic Metabolism and Cancer Susceptibility

    • O. Pelkonen, K. Vähäkangas, H. Raunio

    Pages 253-269

16. Animal Models for Mechanistic Cancer Research

    • Zhao-Qi Wang

    Pages 271-288

17. New Promising Chemopreventive Agents and Mechanisms

    • C. Gerhäuser, N. Frank

    Pages 289-305

18. Molecular Epidemiology in Cancer Prevention

    • C. P. Wild

    Pages 307-321

19. Back Matter

    Pages 323-329

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A large proportion of cancers is preventable. External factors, discovered by epidemiological studies during the last 50 years, account for a majority of all cancer deaths. However, still rather little is known, about how environmental and genetic factors interact, how they may regulate gene activation etc. And it is a long way from the discovery of a basic regulatory mechanism to practical patient treatment. This volume describes the present state of the art in carcinogenesis, possibilities for cancer prevention, and gives genetic background in cancer development. Attention is given to the host-environment interaction, considering how this interaction may lead to cancer formation and how it can be utilised in cancer prevention. The molecular basis for cancer development and the molecular basis for prevention are described.

• angiogenesis
• apoptosis
• cancer genomics
• cancer prevention
• carcinogenesis
• lead
• xenobiotics

• Unit of Chemoprevention, International Agency for Research on Cancer, Lyon, France

  Harri U. Vainio

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