Skip to main content
SpringerLink
Log in
Book cover
  • Conference proceedings
  • © 1989

Inotropic Stimulation and Myocardial Energetics

Editors:

  1. Hj. Just
    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Ch. Holubarsch
    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  3. H. Scholz
    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Sections

Buy it now

eBook USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

This is a preview of subscription content, log in via an institution to check for access.

Table of contents (25 papers)

  1. Front Matter

    Pages I-IX
    PDF

  2. Cellular and subcellular mechanisms, energy turnover

    1. Front Matter

      Pages 1-1
      PDF

    5. On the mechanism of positive inotropic effects of alpha-adrenoceptor agonists

      • Wilhelm Schmitz, C. Kohl, J. Neumann, H. Scholz, J. Scholz
      Pages 23-33

    8. Genetic and non-genetic control of myocardial calcium

      • Norman R. Alpert, E. M. Blanchard, L. A. Mulieri, R. Nagai, A. Zarain-Herberg, M. Periasamy
      Pages 55-66

  3. Pharmacology of positive inotropic substances

    1. Front Matter

      Pages 67-67
      PDF

    4. Ca-Agonists: a new class of inotropic drugs

      • M. Bechem, R. Gross, S. Hebisch, M. Schramm
      Pages 105-116

  4. Clinical experience with positive inotropic substances

    1. Front Matter

      Pages 145-145
      PDF

    2. Influence of isoproterenol on myocardial energetics. Experimental and clinical investigations

      • Gerd Hasenfuss, C. Holubarsch, E. M. Blanchard, L. A. Mulieri, N. R. Alpert, Hj. Just
      Pages 147-155

    3. Effects of long-term xamoterol therapy on the left ventricular mechanical efficiency in patients with ischemic heart disease

      • H. Pouleur, C. van Eyll, J. Etienne, H. van Mechelen, A. Vuylsteke, M. F. Rousseau
      Pages 157-162
Back to top

About this book

Inotropic stimulation of the myocardium, as well as vasodilation and diuresis as essential principles in the treatment of congestive heart failure have recently met with considerable criticism and reevaluation. It is generally agreed that unloading of the heart, either through vasodilation and/or diuresis, improves the working conditions of the dilated, failing heart. It reduces myocar­ dial oxygen consumption through reduction of chamber radius and, thereby, wall tension as the major determinants of myocardial oxygen consumption. Inotropic stimulation, quite in contrast, does not conserve oxygen. It rather consumes energy and that may be disadvantageous in situations of compromised oxygen supply and energy metabolism of the working myocardium. However, under conditions of suf­ ficient oxygen supply and metabolic support inotropic stimulation may bring about in­ creased pumping and subsequent improvement of myocardial failure. In recent years it could convincingly be demonstrated that vasodilation leads to symp­ tomatic improvement of congestive heart failure, improvement of exercise tolerance, and it prolongs life - especially in the case of ACE-inhibitors and the combination of hydra­ lazine with long-acting nitrates. Quite in contrast, equally beneficial effects could not be demonstrated for inotropic agents in congestive heart failure. Only for the cardiac glyco­ sides has it been shown that beneficial effects can be achieved, especially if atrial fibril­ lation with absolute arrhythmia is present. The influence of the cardiac glycosides on the latter represents an effect which is independent of the inotropic action.
Back to top

Keywords

Back to top

Bibliographic Information

  • Book Title: Inotropic Stimulation and Myocardial Energetics

  • Editors: Hj. Just, Ch. Holubarsch, H. Scholz

  • DOI: https://doi.org/10.1007/978-3-662-07908-9

  • Publisher: Steinkopff Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1989

  • Softcover ISBN: 978-3-662-07910-2Published: 28 December 2012

  • eBook ISBN: 978-3-662-07908-9Published: 14 March 2013

  • Edition Number: 1

  • Number of Pages: IX, 273

  • Number of Illustrations: 29 b/w illustrations

  • Additional Information: Jointly published with Springer-Verlag New York: ISBN 0-387-91361-0

  • Topics: Cardiology, Human Physiology

Back to top

Publish with us

Policies and ethics

Back to top
Access via your institution

Buy it now

eBook USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Search

Navigation