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CNS Neuroprotection

  • Book
  • © 2002

Overview

Editors:
  1. Frank W. Marcoux

    1. Pfizer Global Research and Development, Ann Arbor Laboratories, Ann Arbor, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Dennis W. Choi

    1. Department of Neurology Box 8111, Washington University School of Medicine, St. Louis, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 155)

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Table of contents (17 chapters)

  1. Front Matter

    Pages I-XXII
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  2. Mechanic Approaches to CNS Neuroprotection

    1. Front Matter

      Pages 1-1
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    2. Blocking Excitotoxicity

      • A. H. Kim, G. A. Kerchner, D. W. Choi
      Pages 3-36

    3. Limiting Apoptosis as a Strategy for CNS Neuroprotection

      • K. K. W. Wang
      Pages 37-63

    4. Reducing Neuroinflammation

      • K. J. Becker, J. M. Hallenbeck
      Pages 65-93

    5. Mitochondrial Approaches to Neuroprotection

      • M. F. Beal
      Pages 95-113

    6. Stabilizing Calcium Homeostasis

      • M. P. Mattson
      Pages 115-153

    7. Blocking Nitric Oxide Toxicity

      • M. Sasaki, T. M. Dawson, V. L. Dawson
      Pages 155-173

  4. CNS Delivery of Neuroprotective Therapies

    1. Front Matter

      Pages 299-299
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    2. Ex Vivo Gene Therapy in the Central Nervous System

      • A. Blesch, M. H. Tuszynski
      Pages 301-333

    3. Developing Gene-Based Neuroprotection Strategies Using Herpes Amplicon Vectors

      • M. W. Halterman, H. J. Federoff
      Pages 335-357
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Keywords

About this book

"CNS neuroprotection" was a common subject of papers, symposia, and reviews during the previous "decade of the brain. " Indeed, in recent years, experimental study of putative neuroprotective agents prompted clinical trials of numerous drug candidates in acute and chronic human neurodegenerative conditions. While the outcomes of these trials have not been as successful as initially hoped, these were early explorations, and the pipeline of relevant ideas continues to grow in strength and depth. We predict that early in this new millennium, crippling disorders such as stroke and Alzheimer's disease will be treated effectively by therapeutic neuroprotective strategies. This volume of the Handbook of Experimental Pharmacology titled eNS Neuroprotection provides a pharmacological perspective on currently promis­ ing neuroprotective approaches, and a clinical perspective on the challenges involved in establishing the efficacy of these approaches through appropriate clinical trials. Section I, "Mechanistic Approaches to CNS Neuroprotection," reviews major injury mechanisms that have formed the basis for many past and present clinical trials conducted around the world. Dr. KIM and colleagues, Washington University School of Medicine, review the status of blocking excitotoxicity as an approach to CNS neuroprotection. Dr. WANG, Pfizer Global Research and Development,Ann Arbor Laboratories, outlines evidence supporting a contri­ bution of apoptosis to pathological neuronal or glial cell loss. Drs. BECKER and HALLENBECK, University of Washington and the National Institute on Neuro­ logical Diseases and Stroke, respectively, argue that inhibiting inflammatory pathways in the brain can be neuroprotective. Dr.

Editors and Affiliations

  • Pfizer Global Research and Development, Ann Arbor Laboratories, Ann Arbor, USA

    Frank W. Marcoux

  • Department of Neurology Box 8111, Washington University School of Medicine, St. Louis, USA

    Dennis W. Choi

Bibliographic Information

  • Book Title: CNS Neuroprotection

  • Editors: Frank W. Marcoux, Dennis W. Choi

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-662-06274-6

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2002

  • Hardcover ISBN: 978-3-540-42412-3Published: 10 July 2002

  • Softcover ISBN: 978-3-642-07625-1Published: 01 December 2010

  • eBook ISBN: 978-3-662-06274-6Published: 11 November 2013

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: XXII, 500

  • Number of Illustrations: 78 b/w illustrations, 5 illustrations in colour

  • Topics: Pharmacology/Toxicology, Neurosciences, Neurology

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