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Clostridium difficile

  • Book
  • © 2000

Overview

Editors:
  1. Klaus Aktories

    1. Institut für Pharmakologie und Toxikologie, Albert-Ludwigs-Universität Freiburg, Freiburg i. Br., Germany

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  2. Tracy D. Wilkins

    1. Virginia Tech, Fralin Biotechnology Center, Blacksburg, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 250)

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Table of contents (7 chapters)

  1. Front Matter

    Pages i-ix
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  2. Microbiology, Epidemiology and Diagnosis of Clostridium difficile Infection

    • J. S. Brazier, S. P. Borriello
    Pages 1-33

  3. Genetics of Clostridium difficile Toxins

    • J. S. Moncrief, T. D. Wilkins
    Pages 35-54

  4. Molecular Mode of Action of the Large Clostridial Cytotoxins

    • I. Just, F. Hofmann, K. Aktories
    Pages 55-83

  5. Cytotoxic Effects of the Clostridium difficile Toxins

    • M. Thelestam, E. Chaves-Olarte
    Pages 85-96

  6. Large Clostridial Cytotoxins as Tools in Cell Biology

    • I. Just, P. Boquet
    Pages 97-107

  7. Pathogenesis and Clinical Manifestations of Clostridium difficile Diarrhea and Colitis

    • R. J. Farrell, J. T. LaMont
    Pages 109-125

  8. Treatment of Clostridium difficile-Associated Diarrhea and Colitis

    • D. N. Gerding
    Pages 127-139

  9. Back Matter

    Pages 141-146
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Keywords

About this book

Clostridium difficile has been recognized as the cause of a broad spectrum of enteric disease ranging from mild antibiotic-associated diarrhea to pseudomembranous colitis. This volume gives new insights into the microbiology, diagnostics and epidemiology of Clostridium difficile and describes recent strategies in treatment of diseases caused by this agent. Main parts of the volume are devoted to Clostridium difficile toxins A and B which are the major virulence factors. The molecular biology, biochemistry, pharmacology and cell biology of these toxins which are the prototypes of a new family of large clostridial cytotoxins is described in great detail. Clostridium difficile toxins act as glucosyltransferases to inactivate small GTP-binding proteins of the Rho family which are involved in regulation of the actin cytoskeleton, cell adhesion and various signaling processes.

Editors and Affiliations

  • Institut für Pharmakologie und Toxikologie, Albert-Ludwigs-Universität Freiburg, Freiburg i. Br., Germany

    Klaus Aktories

  • Virginia Tech, Fralin Biotechnology Center, Blacksburg, USA

    Tracy D. Wilkins

Bibliographic Information

  • Book Title: Clostridium difficile

  • Editors: Klaus Aktories, Tracy D. Wilkins

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-662-06272-2

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2000

  • Hardcover ISBN: 978-3-540-67291-3Published: 06 July 2000

  • Softcover ISBN: 978-3-642-08668-7Published: 19 October 2010

  • eBook ISBN: 978-3-662-06272-2Published: 17 April 2013

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: IX, 150

  • Topics: Microbiology, Pharmacology/Toxicology, Cell Biology, Molecular Medicine

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