Calreticulin

1. Front Matter

   Pages i-xiii

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2. A Current History of Calreticulin

   • Marek Michalak, Christi Andrin

   Pages 1-10

3. Basic Characteristics and Ion Binding to Calreticulin

   • Shairaz Baksh, Marek Michalak

   Pages 11-30

4. The Intracellular Distribution and Expression of Calreticulin

   • Michal Opas

   Pages 31-41

5. The Roles of Calnexin and Calreticulin as Endoplasmic Reticulum Molecular Chaperones

   • Frank Parlati, Richard Hemming, Wei-Jia Ou, John J. M. Bergeron, David Y. Thomas

   Pages 43-57

6. Calreticulin and Ca2+ Storage

   • Karl-Heinz Krause

   Pages 59-76

7. Calreticulin and the Modulation of Gene Expression

   • Nasrin Mesaeli

   Pages 77-88

8. Role of Calreticulin in Rubella Virus Replication

   • Chintamani D. Atreya, Gregory P. Pogue, Nishi K. Singh, Hira L. Nakhasi

   Pages 89-115

9. Calreticulin and Autoimmunity

   • Richard D. Sontheimer, Tho Q. Nguyen, Shih-Tsung Cheng, Tsu-San Lieu, J. Donald Capra

   Pages 117-139

10. Calreticulin in T Lymphocytes

    • R. Chris Bleackley, Michael J. Pinkoski, Eric A. Atkinson

    Pages 141-153

11. Calreticulin and Thrombosis

    • David J. Pinsky, Keisuke Kuwabara, Ann Marie Schmidt, Charles A. Lawson, Claude Benedict, Johan Broekman et al.

    Pages 155-168

12. Calreticulin in Vector Arthropods—The Secreted Calreticulin

    • Deborah C. Jaworski, Glen R. Needham

    Pages 169-180

13. Protein Nuclear Import is Modulated by Calreticulin

    • Victor B. Hatcher, Christina Samathanam

    Pages 181-200

14. Back Matter

    Pages 201-213

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This book is about calreticulin, a multifunctional calcium binding protein first discovered over 20 years ago. The protein has been described in various locations: endoplasmic reticulum, nuclear envelope, cytoplasmic granules, nucleus, cell surface and even secreted into the blood stream. This volume outlines the newly discovered functions for calreticulin including its control of calcium homeostasis, modulation of steroid-sensitive gene expression, control of viral RNA replication, modulation of nuclear transport, role in T lymphocyte activation and cytotoxic killing, chaperone function, control of adhesion-dependent signaling via integrins, possible role in the biology of ticks, in the pathology of autoimmune diseases and in blood function.

• Activation
• Calcium
• RNA
• autoimmune disease
• biology
• cell
• chaperone
• chaperones
• endoplasmic reticulum
• gene
• gene expression
• protein
• replication

• MRC Group in Molecular Biology of Membranes, Department of Biochemistry, University of Alberta, Edmonton, Canada

  Marek Michalak

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