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Small Molecule — Protein Interactions

  • Conference proceedings
  • © 2003

Overview

Editors:
  1. H. Waldmann

    1. Max-Planck-Institut für Molekulare Physiologie, Dortmund, Germany
      Universität Dortmund, Fachbereich 3, Organische Chemie, Dortmund, Germany

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    You can also search for this editor in PubMed   Google Scholar

  2. M. Koppitz

    1. Medicinal Chemistry, Schering AG, Berlin, Germany

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Ernst Schering Foundation Symposium Proceedings (SCHERING FOUND, volume 42)

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Table of contents (13 papers)

  1. Front Matter

    Pages I-XV
    Download chapter PDF

  2. Drug Discovery Opportunities

    • J. Reinhard-Rupp, G. Wess
    Pages 1-10

  3. Target Analysis: A Priori Assessment of Druggability

    • A. L. Hopkins, C. R. Groom
    Pages 11-17

  4. Drug Discovery at Signaling Interfaces

    • J. Wells, M. Arkin, A. Braisted, W. DeLano, B. McDowell, J. Oslob et al.
    Pages 19-27

  5. Chemical Genomics of Orphan Nuclear Receptors

    • T. Willson
    Pages 29-42

  6. High-Throughput X-Ray Techniques and Drug Discovery

    • H. Jhoti
    Pages 43-58

  7. NMR in Medicinal Chemistry

    • H. Kessler, M. Heller, G. Gemmecker, T. Diercks, E. Planker, M. Coles
    Pages 59-85

  8. Creating Knowledge from High-Throughput Screening Data

    • M. F. M. Engels
    Pages 87-101

  9. From Structure to Recognition Principles: Mining in Crystal Data as a Prerequisite for Drug Design

    • G. Klebe
    Pages 103-126

  10. Practical Database Screening with Docking Tools

    • M. Stahl, T. Schulz-Gasch
    Pages 127-151

  11. De Novo Design Methods

    • H. Briem
    Pages 153-166

  12. From Protein Domains to Drug Candidates — Natural Products as Guiding Principles in Compound Library Design and Synthesis

    • R. Breinbauer, I. R. Vetter, H. Waldmann
    Pages 167-188

  13. Discovery of New MCRs, Chemical Evolution and Lead Optimization

    • L. Weber
    Pages 189-199

  14. The Impact of Combinatorial Chemistry on Drug Discovery

    • P. H. H. Hermkens, G. Müller
    Pages 201-220

  15. Back Matter

    Pages 221-228
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Keywords

About this book

Based on the international workshop on 'Small Molecule - Protein Interactions' held in Berlin, April 24-26, 2002, researchers from industry and academic laboratories describe novel and efficient ways selecting promising new drug targets and developing small molecule inhibitors against them. The structure of the book corresponds to the different aspects of the drug discovery process. All chapters are written by leading experts in the field, who present and discuss the most recent state-of-the-art tools and techniques for the development of novel drugs. The value of the book lies in surveying and summarizing the approaches taken by different companies and institutions giving the reader a balanced view on the use of the latest techniques on the one hand and experience-based assistance in selecting appropriate tools for their own work on the other hand.

Editors and Affiliations

  • Max-Planck-Institut für Molekulare Physiologie, Dortmund, Germany

    H. Waldmann

  • Universität Dortmund, Fachbereich 3, Organische Chemie, Dortmund, Germany

    H. Waldmann

  • Medicinal Chemistry, Schering AG, Berlin, Germany

    M. Koppitz

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