New Concepts in Pathology and Treatment of Autoimmune Disorders

1. Front Matter

   Pages I-XIII

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2. Microarray Technology in the Pathogenesis and Management of Autoimmune Disorders

   • J.-X. She, S. Eckenrode, Q.-G. Ruan, M. P. Marron, Q.-Z. Li, M. C. K. Yang et al.

   Pages 1-14

3. Multiple Sclerosis Perspective

   • G. Ristori, R. Bomprezzi, C. Buttinelli, C. Montesperelli, S. Cannoni, A. Perna et al.

   Pages 15-24

4. Type 1 Diabetes and Multiple Sclerosis: Similarities and Dissimilarities

   • P. Pozzilli, G. Coppolino, L. Monetini, L. Nisticò

   Pages 25-35

5. Immunotherapeutic Strategies for Multiple Sclerosis

   • R. Hohlfeld

   Pages 37-68

6. Specific Immunotherapy of Multiple Sclerosis by Altered Peptide Ligands — Risk or Benefit?

   • B. Bielekova, R. Martin

   Pages 69-87

7. Mucosal Immunity — A Key to Tolerance

   • T. T. MacDonald, S. Nagata, P. D. Fairclough, C. McKenzie

   Pages 89-99

8. New Strategies in Clinical Islet Cell Transplantation

   • T. Berney, C. Ricordi

   Pages 101-121

9. Autologous Hematopoietic Stem Cell Transplantation for Autoimmune Disease

   • J. R. Passweg, A. Gratwohl, A. Tyndall

   Pages 123-132

10. Back Matter

    Pages 133-139

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Autoimmunity, characterized by autoreactive lymphocytes and autoantibodies, is the consequence of a failure to discriminate between self and non-self, and autoimmune diseases are an increasing threat to people living in the industrialized countries. Autoimmune disorders are treatable, but not curable, and patients can face disability at later stages of the disease. Thus, there is a medical and economic need for new concepts and treatments in autoimmune disorders. New concepts and treatments can only be achieved by an interdisciplinary approach bringing together expertise, technologies, and clinical experience. The workshop focused on multiple sclerosis, rheumatoid arthritis and type I diabetes, and discussed conventional drug therapies, gene therapy, cell and tissue transplantation therapies, and first treatments using blood stem cells for reprogramming the patients' immune system.

• Arthritis
• Diabetes mellitus
• Gene Array Assays
• Magnetic Resonance Imaging
• Multiple Sclerosis
• Rheumatoid Arthritis
• Transplantation
• gene therapy

• Clinical Neurology II, Department of Neurological Sciences, Universita la Sapienza, Rome, Italy

  C. Pozzilli

• Unit for Prevention of Diabetes and Metabolic Diseases, University Campus Bio-Medico, Rome, Italy

  P. Pozzilli

• Schering AG, Berlin, Germany

  J.-F. Kapp

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