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Neurodegenerative Disorders: Loss of Function Through Gain of Function

  • Conference proceedings
  • © 2001

Overview

Editors:
  1. Konrad Beyreuther

    1. ZMBH, University of Heidelberg, Heidelberg, Germany

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  2. Yves Christen

    1. Pour la Recherche Thérapeutique, Fondation IPSEN, Paris Cedex 16, France

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    You can also search for this editor in PubMed   Google Scholar

  3. Colin L. Masters

    1. Department of Pathology and The Mental Health Institute of Victoria, The University of Melbourne, Parkville, Australia

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Research and Perspectives in Alzheimer's Disease (ALZHEIMER)

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Table of contents (13 papers)

  1. Front Matter

    Pages I-XIV
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  2. The Natural History of Alzheimer’s Disease: Minding the Gaps in Understanding the Mechanisms of Neurodegeneration

    • C. L. Masters, K. Beyreuther
    Pages 1-21

  3. Mechanisms of Motor Neuron Death in ALS

    • T. L. Williamson, D. W. Cleveland
    Pages 23-40

  4. Pathological Mechanisms in Huntington’s Disease and Other Polyglutamine Expansion Diseases

    • A. Lunkes, G. Yvert, Y. Trottier, D. Devys, J. L. Mandel
    Pages 41-53

  5. Prion Protein Biogenesis: Implications for Neurodegeneration

    • V. R. Lingappa, R. S. Hegde
    Pages 55-66

  6. The Value of Transgenic Models for the Study of Neurodegenerative Diseases

    • D. L. Price, P. C. Wong, A. L. Markowska, G. Thinakaran, M. K. Lee, L. J. Martin et al.
    Pages 67-86

  7. Pathogenesis and Mechanism of Cerebral Amyloidosis in APP Transgenic Mice

    • M. Jucker, M. Calhoun, A. Phinney, M. Stalder, L. Bondolfi, D. Winkler et al.
    Pages 87-95

  8. Alzheimer’s Disease: Physiological and Pathogenetic Role of the Amyloid Precursor Protein (APP), its Aβ-Amyloid Domain and Free Aβ-Amyloid Peptide

    • K. Beyreuther, C. L. Masters
    Pages 97-117

  9. The NEXT Step in Notch Processing and its Relevance to Amyloid Precursor Protein

    • R. Kopan, S. Huppert, J. S. Mumm, M. T. Saxena, E. H. Schroeter, W. J. Ray et al.
    Pages 119-128

  10. The Putative Role of Presenilins in the Transmembrane Domain Cleavage of Amyloid Precursor Protein and Other Integral Membrane Proteins

    • B. De Strooper, A. Herreman, P. Cupers, K. Craessaerts, L. Serneels, W. Annaert
    Pages 129-140

  11. ApoE Receptors in the Brain: Novel Signaling Pathways with Potential Relevance for Alzheimer’s Disease

    • J. Herz, U. Beffert, T. Hiesberger, M. Gotthardt
    Pages 141-148

  12. Homeoprotein Intercellular Tansport: Mechanisms, Significance and Applications

    • B. Allinquant, G. Mainguy, A. Prochiantz
    Pages 149-158

  13. Overexpression of APPL, a Drosophila APP Homologue, Compromises Microtubule Associated Axonal Transport and Promotes Synapse Formation

    • L. Torroja, M. Packard, V. Budnik, K. White
    Pages 159-171

  14. A Gain of Function of the Huntington’s Disease and Amyotrophic Lateral Sclerosis-Associated Genetic Mutations May Be a Loss of Bioenergetics

    • M. F. Beal
    Pages 173-185

  15. Back Matter

    Pages 187-189
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Keywords

About this book

A fundamental change is occurring in the understanding of the major neurodegenerative disorders. Protein aggregation is a common emerging theme in diseases as diverse as Alzheimer's, Creutzfeld-Jakob, Parkinson's, and amyotrophic lateral sclerosis. If valid, then a small number of diagnostic and rational therapeutic strategies will emerge over the next few years, based on the common theme of modulation of the production, turnover and deposition of these aggregating proteins. The book provides insights into the cellular and animal models of these diseases, and how the molecular basis of neurodegeneration has become the preferred target of therapy.

Editors and Affiliations

  • ZMBH, University of Heidelberg, Heidelberg, Germany

    Konrad Beyreuther

  • Pour la Recherche Thérapeutique, Fondation IPSEN, Paris Cedex 16, France

    Yves Christen

  • Department of Pathology and The Mental Health Institute of Victoria, The University of Melbourne, Parkville, Australia

    Colin L. Masters

Bibliographic Information

  • Book Title: Neurodegenerative Disorders: Loss of Function Through Gain of Function

  • Editors: Konrad Beyreuther, Yves Christen, Colin L. Masters

  • Series Title: Research and Perspectives in Alzheimer's Disease

  • DOI: https://doi.org/10.1007/978-3-662-04399-8

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2001

  • Hardcover ISBN: 978-3-540-41218-2Published: 13 March 2001

  • Softcover ISBN: 978-3-642-07448-6Published: 06 December 2010

  • eBook ISBN: 978-3-662-04399-8Published: 29 June 2013

  • Series ISSN: 0945-6066

  • Series E-ISSN: 2196-310X

  • Edition Number: 1

  • Number of Pages: XIV, 189

  • Number of Illustrations: 21 b/w illustrations, 8 illustrations in colour

  • Topics: Neurosciences

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