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Neuronal Death by Accident or by Design

  • Conference proceedings
  • © 2001

Overview

Editors:
  1. Christopher E. Henderson

    1. INSERM U.382 — IBDM (CNRS — INSERM — Univ. Méditerranée), Marseille Cedex 09, France

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  2. Douglas R. Green

    1. Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, USA

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  3. Jean Mariani

    1. Institut des Neurosciences, UMR 7624, CNRS et Université Pierre et Marie Curie, Paris, France

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  4. Yves Christen

    1. Pour la Recherche Thérapeutique, Fondation IPSEN, Paris Cedex 16, France

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Part of the book series: Research and Perspectives in Neurosciences (NEUROSCIENCE)

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Table of contents (11 papers)

  1. Front Matter

    Pages I-XI
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  2. Mitochondria and Apoptosis, the Stepping Stones on the Path to Death

    • D. W. Ethell, D. R. Green
    Pages 1-13

  3. Mitochondrial Membrane Permeabilization in Physiological and Pathological Cell Death

    • L. Ravagnan, G. Kroemer
    Pages 15-26

  4. Bcl-2 Family Members and Permeabilization of the Outer Mitochondrial Membrane

    • O. Terradillos, X. Roucou, S. Da Cruz, B. Sanchez, J.-C. Martinou
    Pages 27-32

  5. Roles for Fas in Programmed Cell Death of Motoneurons

    • C. Raoul, G. Ugolini, A. Estevez, B. Pettmann, C. E. Henderson
    Pages 33-45

  6. Events that Commit Neurons to Die After Trophic Factor Deprivation

    • G. V. Putcha, M. Deshmukh, E. M. Johnson Jr.
    Pages 47-60

  7. Normal Programmed Cell Death of Developing Avian and Mammalian Neurons Following Inhibition or Genetic Deletion of Caspases

    • R. W. Oppenheim, C.-Y. Kuan, D. Prevette, P. Rakic, H. Yaginuma
    Pages 61-74

  8. Caspases and Their Regulation in Apoptosis during Brain Development

    • C.-Y. Kuan, R. A. Flavell, P. Rakic
    Pages 75-88

  9. Apoptotic Neurodegeneration in the Developing Brain

    • C. Ikonomidou
    Pages 89-96

  10. Apoptosis, Glial Cells and Parkinson’s Disease

    • E. C. Hirsch
    Pages 97-107

  11. Mechanisms of Neuronal Death: An in vivo Study in the Lurcher Mutant Mice

    • F. Selimi, A. Campana, J. Bakouche, A. Lohof, M. W. Vogel, J. Mariani
    Pages 109-135

  12. Neuronal Death in Huntington’s Disease: Multiple Pathways for One Issue?

    • S. Humbert, F. Saudou
    Pages 137-152

  13. Back Matter

    Pages 153-154
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Keywords

About this book

Four chapters represent the intense current effort to understand the way in which the mitochondrion controls the activation of the final stages of cell death. Another four articles attack the problem from the other side. How do specific insults in particular human or mouse neuro-degenerative diseases translate into mechanisms that will not only allow us to better understand what is happening in these patients but also, with luck, allow for development of more efficient and specific drugs in the future? Firstly, the concept of a central common cell death pathway, originally derived from studies on the nematode, has been an outstanding productive paradigm in bringing together different strands of research. Secondly, truly striking links have been made between results obtained in the culture dish (or even cell-free systems) and the diseased human brain.

Editors and Affiliations

  • INSERM U.382 — IBDM (CNRS — INSERM — Univ. Méditerranée), Marseille Cedex 09, France

    Christopher E. Henderson

  • Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, USA

    Douglas R. Green

  • Institut des Neurosciences, UMR 7624, CNRS et Université Pierre et Marie Curie, Paris, France

    Jean Mariani

  • Pour la Recherche Thérapeutique, Fondation IPSEN, Paris Cedex 16, France

    Yves Christen

Bibliographic Information

  • Book Title: Neuronal Death by Accident or by Design

  • Editors: Christopher E. Henderson, Douglas R. Green, Jean Mariani, Yves Christen

  • Series Title: Research and Perspectives in Neurosciences

  • DOI: https://doi.org/10.1007/978-3-662-04333-2

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2001

  • Hardcover ISBN: 978-3-540-41777-4Published: 25 September 2001

  • Softcover ISBN: 978-3-642-07517-9Published: 03 December 2010

  • eBook ISBN: 978-3-662-04333-2Published: 14 March 2013

  • Series ISSN: 0945-6082

  • Series E-ISSN: 2196-3096

  • Edition Number: 1

  • Number of Pages: XI, 154

  • Number of Illustrations: 40 b/w illustrations, 18 illustrations in colour

  • Topics: Neurosciences, Neurology

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