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Therapeutic Angiogenesis

  • Conference proceedings
  • © 1999

Overview

Editors:
  1. J. A. Dormandy
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  2. W. P. Dole
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  3. G. M. Rubanyi
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  • First book on Therapeutic Angiogenesis
  • First book on Angiogenic Gene Therapy
  • First book to review better basic science and clinical applications of Therapeutic Angiogenesis

Part of the book series: Ernst Schering Foundation Symposium Proceedings (SCHERING FOUND, volume 28)

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Table of contents (10 papers)

  1. Front Matter

    Pages I-XI
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  2. Angiogenesis, Fibroblast Growth Factors, and Their Receptors

    • A. Baird
    Pages 1-22

  3. Integrins and Angiogenesis

    • K. S. Riddelle-Spencer, D. A. Cheresh
    Pages 23-39

  4. Mechanisms of Brain Angiogenesis in Health and Disease

    • K. H. Plate
    Pages 41-56

  5. TIE Receptors and Angiopoietins: Novel Modulators of Angiogenesis

    • T. N. Sato
    Pages 57-65

  6. Collateral and Capillary Formation — A Comparison

    • E. Deindl, W. Schaper
    Pages 67-86

  7. Hemodynamic Forces, Exercise, and Angiogenesis

    • O. Hudlická, M. D. Brown
    Pages 87-123

  8. Myocardial Ischemia and Growth Factor Therapy

    • M. Simons
    Pages 125-145

  9. Angiogenic Gene Therapy for Coronary Artery Disease

    • R. L. Engler
    Pages 147-161

  10. Transmyocardial Laser Use for Endstage Coronary Artery Disease

    • S. F. Aranki, F. Mannting, S. K. Shernan, N. C. Cummings, S. P. Sears, L. H. Cohn
    Pages 163-173

  11. Vascular Gene Therapy — Early Clinical Results with Angiogenic Growth Factors

    • S. Ylä-Herttuala
    Pages 175-181

  12. Back Matter

    Pages 183-186
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Keywords

About this book

Over the past decade, rapid progress had been made in elucidating the cellular and molecular mechanisms of new blood vessel formation in both health and disease. Lack of sufficient angiogenesis (new capillary development) and collateral formation (remodeling of existing blood vessels) in adult tissues (e. g. , heart, brain, skeletal muscle) during criti­ cal ischemia has prompted novel therapeutic strategies to stimulate/fa­ cilitate angiogenesis and collateral formation in ischemic conditions ("therapeutic angiogenesis"). Therapeutic angiogenesis describes a strategy of inducing new col­ lateral vessels that can bypass vascular obstructions caused by atherosclerotic disease and stimulating new capillaries that can en­ hance tissue oxygen exchange. Naturally occurring growth factors (e. g. , FGFs, VEGFs) have been identified and demonstrated to induce new blood vessel formation in the adult organism. The therapeutic ap­ plication of these growth factors has been demonstrated to enhance these natural processes and have been shown in a number of animal models to increase blood flow and oxygen exchange to ischemic tis­ sues. Therapeutic angiogenesis therefore represents a new medical principle that is anticipated to be used as an adjunct or alternative to angioplasty and/or bypass surgery. A number of strategies have been proposed and tested to deliver growth factors. One strategy is the direct administration of the growth factor protein by intramuscular, intraarte­ rial or intravenous delivery.

Bibliographic Information

  • Book Title: Therapeutic Angiogenesis

  • Editors: J. A. Dormandy, W. P. Dole, G. M. Rubanyi

  • Series Title: Ernst Schering Foundation Symposium Proceedings

  • DOI: https://doi.org/10.1007/978-3-662-03776-8

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1999

  • Softcover ISBN: 978-3-662-03778-2Published: 19 December 2012

  • eBook ISBN: 978-3-662-03776-8Published: 14 March 2013

  • Series ISSN: 0947-6075

  • Edition Number: 1

  • Number of Pages: XI, 186

  • Number of Illustrations: 21 b/w illustrations

  • Topics: Cardiology, Angiology

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