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Molecular Basis of Sex Hormone Receptor Function

New Targets for Intervention

  • Conference proceedings
  • © 1998

Overview

Editors:
  1. H. Gronemeyer

    1. Institute of Genetics and Molecular and Cell Biology, Parc d’Innovation, Illkirch Cedex, France

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  2. U. Fuhrmann

    1. Fertility Control and Hormone Therapy, Schering AG, Berlin, Germany

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    You can also search for this editor in PubMed   Google Scholar

  3. K. Parczyk

    1. Experimental Oncology, Schering AG, Berlin, Germany

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Ernst Schering Foundation Symposium Proceedings (SCHERING FOUND, volume 24)

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Table of contents (12 papers)

  1. Front Matter

    Pages I-XIV
    Download chapter PDF

  2. Nuclear Receptors as Targets for Drug Design: New Options and Old Challenges

    • M. J. S. Heine, H. Gronemeyer
    Pages 1-41

  3. The Androgen Receptor Co-regulator, ARA70

    • H. Miyamoto, S. Yeh, S.-B. Hwang, N. Fujimoto, P. Hsiao, H. Ting et al.
    Pages 43-51

  4. Role of Coactivators in Transcriptional Activation by Estrogen Receptors

    • M. G. Parker, D. Heery, E. Kalkhoven, J. Valentine
    Pages 53-61

  5. A Search for a Mechanism for the Antiinflammatory Action of Glucocorticoids

    • A. C. B. Cato
    Pages 63-87

  6. Activation of Progesterone and Androgen Receptors by Signal Transduction Pathways

    • N. L. Weigel, L. V. Nazareth, M.-C. Keightley, Y. Zhang
    Pages 89-107

  7. Ligand-Independent Activation of the Estrogen Receptor: Activation by Epidermal Growth Factor and Dopamine

    • O. Donzé, D. Picard
    Pages 109-120

  8. The ER/AP1 Pathway: A Window on the Cell-Specific Estrogen-like Effects of Antiestrogens

    • P. Webb, M.-R. Keneally, J. Shinsako, R. Uht, C. Anderson, K. Paech et al.
    Pages 121-140

  9. A Structural View of the Retinoid Nuclear Receptors

    • B. P. Klaholz, D. Moras
    Pages 141-160

  10. Characterization of Human Estrogen Receptor ß

    • E. Enmark, J.-Å. Gustafsson
    Pages 161-177

  11. Functional and Pharmacological Analysis of the A and B Forms of the Human Progesterone Receptor

    • P. Giangrande, G. Pollio, D. P. McDonnell
    Pages 179-201

  12. Oestrogen Receptor Expression Mutants and Variants in Tamoxifen-Resistant Breast Cancer

    • C. M. W. Chan, M. Dowsett
    Pages 203-215

  13. Structure and Expression of the Androgen Receptor in Prostate Cancer

    • J. Trapman
    Pages 217-232

  14. Back Matter

    Pages 233-238
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Keywords

About this book

How sex hormone receptors and all the other members of the nuclear receptor superfamily do such a remarkable job has fascinated scientists for decades. A series of discoveries in the past few years has dramatically enlightened our understanding of the molecular mechanisms that govern nuclear receptor action. The elucidation of the 3D structures of several nuclear receptor ligand binding domains in the presence of agonists or antagonists has provided an allosteric concept of ligand action, and the discovery of a plethora of ligand-dependent protein interactions has linked this transconformation with the ability of nuclear receptors to act as transcriptional activators and repressors and the enzymatic modification of chromatin and factors of the basal transcriptional machinery.

Editors and Affiliations

  • Institute of Genetics and Molecular and Cell Biology, Parc d’Innovation, Illkirch Cedex, France

    H. Gronemeyer

  • Fertility Control and Hormone Therapy, Schering AG, Berlin, Germany

    U. Fuhrmann

  • Experimental Oncology, Schering AG, Berlin, Germany

    K. Parczyk

Bibliographic Information

  • Book Title: Molecular Basis of Sex Hormone Receptor Function

  • Book Subtitle: New Targets for Intervention

  • Editors: H. Gronemeyer, U. Fuhrmann, K. Parczyk

  • Series Title: Ernst Schering Foundation Symposium Proceedings

  • DOI: https://doi.org/10.1007/978-3-662-03689-1

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1998

  • Softcover ISBN: 978-3-662-03691-4Published: 03 October 2013

  • eBook ISBN: 978-3-662-03689-1Published: 17 April 2013

  • Series ISSN: 0947-6075

  • Edition Number: 1

  • Number of Pages: XIV, 238

  • Number of Illustrations: 58 b/w illustrations

  • Topics: Molecular Medicine

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