Gene Therapy

1. Front Matter

   Pages I-XII

   PDF

2. Human Gene Therapy: Future Prospects

   • M. M. Gottesman

   Pages 1-16

3. Approaches to the Gene Therapy of Cancer Using Replication-Competent Oncolytic Adenoviruses

   • C. Heise, D. H. Kirn, A. Balmain

   Pages 17-25

4. Discovery, Development, and Application of Synthetic Gene Delivery Systems

   • P. L. Felgner

   Pages 27-50

5. Tumor Suppressor Genes

   • B. E. Weissman

   Pages 51-76

6. Oligonucleotide Therapeutics for Human Leukemia

   • A. M. Gewirtz

   Pages 77-95

7. Ribozymes as Biotherapeutic Tools for the Modulation of Gene Expression

   • B. Anderegg, A. Irie, K. J. Scanlon

   Pages 97-130

8. Cardiovascular Gene Therapy

   • R. Engler

   Pages 131-151

9. Protection of Hematopoietic Progenitor Cells from Chemotherapy Toxicity by Transfer of Drug Resistance Genes

   • N. Takebe, S.-C. Zhao, D. Banerjee, J. R. Bertino

   Pages 153-181

10. Pro-drug Gene Therapy for Prostate Cancer

    • H. L. Adler, P. T. Scardino

    Pages 183-194

11. Hematopoietic Ex Vivo Gene Transfer

    • H. Glimm, C. von Kalle, R. Henschler, R. Mertelsmann

    Pages 195-210

12. Immunological Approaches for Gene Therapy of Cancer

    • R. E. Sobol, D. Shawler, C. Van Beveren, M. Garrett, H. Fakhrai, R. Bartholomew et al.

    Pages 211-224

13. Gene Therapy Regulatory Issues in the United States and Europe

    • R. Wikberg-Leonardi

    Pages 225-235

14. Back Matter

    Pages 237-242

    PDF

This book is a collection of preclinical and clinical reports on the application of gene therapy to human disease. The two methods available for delivering therapeutic genes to diseased cells, viral and non-viral vector systems, are detailed and characterized. Several reports describe both approaches currently used in gene therapy: the introduction of a wild-type gene to restore normal gene function in diseased cells, and the use of antisense molecules to hinder abnormal gene expression. Clinical studies detail several different strategies for the treatment of cancer and cardiovascular diseases, using genetic material as therapeutic agents. The regulatory issues governing the use of gene therapy in Europe and the United States are also presented. This book highlights the range of applications and demonstrates the rapid progress being made in the field of gene therapy.

• Expression
• Gentherapie
• Nucleotide
• gene expression
• gene therapy
• gene transfer
• genetic engineering

Policies and ethics