Cellular Therapy

1. Front Matter

   Pages I-XII

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2. Somatic Gene Therapy in Cancer

   • F. M. Rosenthal, C. F. Waller, A. Lindemann, R. Mertelsmann

   Pages 1-24

3. Placental Blood: New Options in Hematopoietic Stem Cell Transplantation

   • R. M. Weber-Nordt, R. Mertelsmann

   Pages 25-36

4. Recent Developments in the Ex Vivo Manipulation of Hematopoietic Cells from Bone Marrow and Blood

   • R. Henschler, J. Winkler, D. Möbest, A. Spyridonidis, W. Lange, R. Mertelsmann

   Pages 37-53

5. Monocyte-Derived Cells in Adoptive Immunotherapy of Cancer: Facts and Perspectives

   • S. W. Krause, B. Hennemann, A. Konur, M. Kreutz, R. Andreesen

   Pages 55-73

6. The Immunological Basis for the Development of Tumor Cell- and Peptide-Based Vaccines for Treatment of Patients with Renal Cell Carcinoma

   • D. J. Schendel, E. Nößner, B. Maget, S. Kressenstein, K. Pantel, R. Oberneder

   Pages 75-86

7. Transplantation of Isolated Islets of Langerhans as Treatment of Diabetes Mellitus

   • K. Federlin, B. J. Hering, R. G. Bretzel

   Pages 87-109

8. Potential Use of Marrow Stromal Cells for Therapy of Osteogenesis Imperfecta and Osteoporosis

   • D. J. Prockop

   Pages 111-118

9. Neuronal Modulation of the Immune Response in Nervous Tissue: Implications for Neurodegenerative and Autoimmune Diseases

   • H. Neumann, H. Wekerle

   Pages 119-128

10. Transplantation of Dopamine-Synthesizing Cells in Parkinson’s Disease: Experimental Data and Clinical Application

    • W. H. Oertel, O. Pogarell, A. Kupsch, A. Hartmann

    Pages 129-144

11. Repairing CNS Demyelination by Glial Cell Transplantation

    • R. J. M. Franklin

    Pages 145-158

12. Monitoring of Suicide Gene Therapy with Positron Emission Tomography

    • U. Haberkorn

    Pages 159-175

13. Back Matter

    Pages 177-180

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The use of cells for the treatment of a variety of diseases is no longer a dream. Today, blood transfusion, bone marrow transplantation, the use of ex vivo cultured skin in wound healing, and peripheral stern cell transplantation, including the ex vivo expansion of hematopoietic stern cells after high-dose chemo/radiation therapy, are routine. This high standard of knowledge and skills in cell transplantation might also re­ sult in tackling hitherto untreatable diseases. Organ transplantation is presently the only life-saving treatment for a variety of conditions. Important findings in cell and molecular biol­ ogy, the identification of hematopoietic, mesenchymal and neuronal stern cells, together with breakthroughs in the methodology for isolat­ ing, purifying, expanding, and storing human cells could make cellular therapy an alternative to organ transplantation in certain diseases within the next decade. Placental blood may be the source of choice in isolating naive progenitor cells for allogeneic transplantation. Immunotherapy is the most hopeful strategy to date for the treat­ ment of tumors resistant to chemotherapy, radiation therapy, or hor­ mone therapy. It includes the use of tumor-infiltrating lymphocytes, ex vivo activated memory T lymphocytes, and cell-based vaccines.

• Cellular Therapy
• Diabetes
• Diabetes mellitus
• Endocrinology
• Islets Of Langerhans
• Neurology
• Oncology
• Parkinson
• Stem Cells
• carcinoma
• clinical application
• gene therapy

Policies and ethics