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Cellular Therapy

  • Conference proceedings
  • © 1997

Overview

Editors:
  1. H. Wekerle
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  2. H. Graf
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  3. J. D. Turner
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Part of the book series: Ernst Schering Foundation Symposium Proceedings (SCHERING FOUND, volume 20)

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Table of contents (11 papers)

  1. Front Matter

    Pages I-XII
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  2. Somatic Gene Therapy in Cancer

    • F. M. Rosenthal, C. F. Waller, A. Lindemann, R. Mertelsmann
    Pages 1-24

  3. Placental Blood: New Options in Hematopoietic Stem Cell Transplantation

    • R. M. Weber-Nordt, R. Mertelsmann
    Pages 25-36

  4. Recent Developments in the Ex Vivo Manipulation of Hematopoietic Cells from Bone Marrow and Blood

    • R. Henschler, J. Winkler, D. Möbest, A. Spyridonidis, W. Lange, R. Mertelsmann
    Pages 37-53

  5. Monocyte-Derived Cells in Adoptive Immunotherapy of Cancer: Facts and Perspectives

    • S. W. Krause, B. Hennemann, A. Konur, M. Kreutz, R. Andreesen
    Pages 55-73

  6. The Immunological Basis for the Development of Tumor Cell- and Peptide-Based Vaccines for Treatment of Patients with Renal Cell Carcinoma

    • D. J. Schendel, E. Nößner, B. Maget, S. Kressenstein, K. Pantel, R. Oberneder
    Pages 75-86

  7. Transplantation of Isolated Islets of Langerhans as Treatment of Diabetes Mellitus

    • K. Federlin, B. J. Hering, R. G. Bretzel
    Pages 87-109

  8. Potential Use of Marrow Stromal Cells for Therapy of Osteogenesis Imperfecta and Osteoporosis

    • D. J. Prockop
    Pages 111-118

  9. Neuronal Modulation of the Immune Response in Nervous Tissue: Implications for Neurodegenerative and Autoimmune Diseases

    • H. Neumann, H. Wekerle
    Pages 119-128

  10. Transplantation of Dopamine-Synthesizing Cells in Parkinson’s Disease: Experimental Data and Clinical Application

    • W. H. Oertel, O. Pogarell, A. Kupsch, A. Hartmann
    Pages 129-144

  11. Repairing CNS Demyelination by Glial Cell Transplantation

    • R. J. M. Franklin
    Pages 145-158

  12. Monitoring of Suicide Gene Therapy with Positron Emission Tomography

    • U. Haberkorn
    Pages 159-175

  13. Back Matter

    Pages 177-180
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Keywords

About this book

The use of cells for the treatment of a variety of diseases is no longer a dream. Today, blood transfusion, bone marrow transplantation, the use of ex vivo cultured skin in wound healing, and peripheral stern cell transplantation, including the ex vivo expansion of hematopoietic stern cells after high-dose chemo/radiation therapy, are routine. This high standard of knowledge and skills in cell transplantation might also re­ sult in tackling hitherto untreatable diseases. Organ transplantation is presently the only life-saving treatment for a variety of conditions. Important findings in cell and molecular biol­ ogy, the identification of hematopoietic, mesenchymal and neuronal stern cells, together with breakthroughs in the methodology for isolat­ ing, purifying, expanding, and storing human cells could make cellular therapy an alternative to organ transplantation in certain diseases within the next decade. Placental blood may be the source of choice in isolating naive progenitor cells for allogeneic transplantation. Immunotherapy is the most hopeful strategy to date for the treat­ ment of tumors resistant to chemotherapy, radiation therapy, or hor­ mone therapy. It includes the use of tumor-infiltrating lymphocytes, ex vivo activated memory T lymphocytes, and cell-based vaccines.

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