Transgenic Animals as Model Systems for Human Diseases

1. Front Matter

   Pages I-XII

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2. The Human Renin-Angiotensin System in Transgenic Rats — New Tools for Antihypertensive Therapy

   • Jürgen Wagner, Martin Paul, Detlev Ganten

   Pages 1-23

3. Probing the Genetics of Atherosclerosis in Transgenic Mice

   • Edward Rubin, Joshua Schultz

   Pages 25-37

4. The PrP-less Mouse: A Tool for Prion Research

   • Charles Weissmann, Hansruedi Büeler, Marek Fischer, Michel Aguet

   Pages 39-56

5. The Carboxyterminal Fragment of the Alzheimer Amyloid Protein Precursor Causes Neurodegeneration In Vivo

   • Rachael L. Neve, Michael R. Kozlowski, Anja Kammerscheidt, Christine F. Hohmann

   Pages 57-72

6. Transgenic Models of Chronic Arthritis and of Systemic Tumour Necrosis Factor-Mediated Disease in Mice Expressing Human Tumour Necrosis Factor

   • George A. Kollias

   Pages 73-90

7. Mammary Neoplasia in Mouse Mammary Tumor Virus-Transforming Growth Factor α Transgenic Mice

   • Robert J. Coffey, Peter J. Dempsey

   Pages 91-108

8. Exploring the Pathogenic Potential of c-fos, Polyoma Middle T and Human Foamy Virus in Transgenic Mice

   • Erwin F. Wagner, Adriano Aguzzi

   Pages 109-128

9. Transgenic Animals as Bioreactors for Therapeutic and Nutritional Proteins

   • Lothar Hennighausen, Avi Shamay, Priscilla A. Furth, Robert A. McKnight, Caird Rexroad Jr., Vern G. Pursel et al.

   Pages 129-141

10. Targeted Inactivation of the Muscle Regulatory Genes Myf-5 and MyoD: Effect on Muscle and Skeletal Development

    • Michael A. Rudnicki, Thomas Braun, Hans-Henning Arnold, Rudolf Jaenisch

    Pages 143-151

Some of the current concepts used in transgenic research, an increasingly important tool to study the regulation and function of genes, are illustrated in this book. With these techniques, animal models can be used to study human diseases; this opens up new possibilities in both applied and basic research. Specifically, the ability to introduce genes into the germline of mice and the successful expression of the inserted gene within an organism provide new insights and opportunities for biomedical research. The discussion here shows how a detailed analysis of the underlying molecular mechanisms will provide new insights into the genetic origin of certain diseases and will lead to a better understanding of normal and abnormal physiological processes.

• Biomedizinische Forschung
• Gentechnologie
• Labormedizin
• biomedical engineering
• gene
• genetic engineering
• genetics
• medicine
• microbiology
• virus

• Research Institute of Molecular Pathology (IMP), Vienna, Austria

  Erwin F. Wagner

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