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Galenics of Insulin

The Physico-chemical and Pharmaceutical Aspects of Insulin and Insulin Preparations

  • Book
  • © 1987

Overview

Authors:
  1. Jens Brange

    1. Novo Research Institute, Bagsvaerd, Denmark

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Table of contents (4 chapters)

  1. Front Matter

    Pages I-X
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  2. Production of Bovine and Porcine Insulin

    • Jens Brange
    Pages 1-6

  3. Characterization of Insulin

    • Jens Brange
    Pages 7-15

  4. Insulin Preparations

    • Jens Brange
    Pages 17-73

  5. Human Insulin

    • Jens Brange
    Pages 75-81

  6. Back Matter

    Pages 83-103
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Keywords

About this book

Galenical pharmacy or galenics is the science dealing with the pro­ duction of drug substances from raw materials, the purity of such substances, their formulation into pharmaceutical preparations with the desired effects and safety in use, and the quality control, stability and storage of the preparations. The field has taken its name from the Greek physician Galen (131-201 A.D.), who had a profound influence on medicine for many centuries because he collected and systematized the medicinal knowledge of his time. The discovery of insulin is attributed to Banting and Best who, in 1921, prepared an extract of the pancreas of the fetal calf and showed that the extract was capable of reducing the blood sugar level of a diabetic dog. This outstanding discovery gave rise to the rapid develop­ ment of the manufacture of insulin of bovine and porcine origin. By 1925, two Danish manufacturers of insulin preparations were established; both have since been in the forefront ofthe development of insulin preparations, the latest achievement being the marketing of human insulin by Novo in 1982. The development of highly purified human insulin produced semisynthetically from porcine insulin or by DNA recombinant methods are significant contributions to safe and efficient insulin therapy. Insulin is a protein which is destroyed in the gastrointestinal tract.

Authors and Affiliations

  • Novo Research Institute, Bagsvaerd, Denmark

    Jens Brange

Bibliographic Information

  • Book Title: Galenics of Insulin

  • Book Subtitle: The Physico-chemical and Pharmaceutical Aspects of Insulin and Insulin Preparations

  • Authors: Jens Brange

  • DOI: https://doi.org/10.1007/978-3-662-02526-0

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1987

  • Softcover ISBN: 978-3-662-02528-4Published: 31 October 2012

  • eBook ISBN: 978-3-662-02526-0Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: X, 103

  • Number of Illustrations: 20 b/w illustrations

  • Topics: Metabolic Diseases, Pharmacy

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