Skip to main content
SpringerLink
Log in
Book cover

Cellular Aspects of Hypertension

  • Conference proceedings
  • © 1991

Overview

Editors:
  1. Giacomo Bruschi

    1. Istituto di Clinica Medica e Nefrologia, Facolta di Medicina e Chirurgia, Università degli Studi di Parma, Parma, Italy

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Alberico Borghetti

    1. Istituto di Clinica Medica e Nefrologia, Facolta di Medicina e Chirurgia, Università degli Studi di Parma, Parma, Italy

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (26 papers)

  1. Front Matter

    Pages I-XII
    Download chapter PDF

  2. Function and Structure of Vascular Tissue

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. Structure and Function of Resistance Vessels in Hypertension

      • M. J. Mulvany
      Pages 3-11

    3. Vascular Smooth Muscle Cell in Hypertension: Dissecting Out Cause and Effect

      • J. D. Swales
      Pages 13-24

    4. Cellular Mechanisms of Spontaneous Hypertension and Stroke: Role of Vascular Smooth Muscle Cells

      • Y. Yamori, Y. Nara, T. Nabika, M. Tagami, R. Horie
      Pages 25-40

    5. Hypertrophic Growth of Vascular Smooth Muscle

      • G. K. Owens
      Pages 41-49

    6. Biomechanical and Electrical Responses of Normal and Hypertensive Veins to Short-Term Pressure Increases

      • E. Monos, K. Kauser, S. J. Contney, A. W. Cowley Jr., W. J. Stekiel
      Pages 51-57

  3. Calcium and Circulatory Control

    1. Front Matter

      Pages 59-59
      Download chapter PDF

    2. Dysfunction of Ca2+-pump of Vascular Muscle Membranes: An Important Etiological Factor in Hypertension

      • C. Y. Kwan
      Pages 61-68

    3. Changes in Ca2+ and Ca2+ Sensitivity During Contraction-Relaxation of Arterial Muscle

      • G. Bruschi, M. E. Bruschi, G. Regolisti, A. Borghetti
      Pages 69-78

    4. Superficial Sarcoplasmic Reticulum Regulates Activated and Steady-State Cytosolic Ca2+ Concentrations in Vascular Smooth Muscle

      • J. Barakeh, M. B. Cannell, R. Khalil, O. Thastrup, C. van Breemen
      Pages 79-89

    5. Subsarcolemmal Increase in Intracellular Ca2+ in Vascular Muscle Cells from Spontaneously Hypertensive Rats

      • K. Hermsmeyer, P. Erne
      Pages 91-96

    6. Pathogenesis of Essential Hypertension: The Sodium Pump Inhibitor (Natriuretic Hormone) — Sodium/Calcium Exchange — Hypertension Hypothesis

      • M. P. Blaustein
      Pages 97-110

    7. Calcium Metabolism and Its Relationship to Blood Pressure in Humans

      • A. Hvarfner
      Pages 111-121

    8. Parathyroids, Hypertension, and Vascular Reactivity

      • A. Gairard, R. Schleiffer, F. Pernot, C. Bergmann, B. van Overloop
      Pages 123-133

    9. Protection Against Hypertensive Cardiovascular Damage by Dihydropyridine Calcium Antagonists

      • J. P. Stasch, S. Kazda, G. Luckhaus, A. Knorr, B. Garthoff, C. Hirth-Dietrich
      Pages 135-147

    10. Nifedipine and Vascular Smooth Muscle Cells in Atherogenesis: In Vivo and In Vitro Studies

      • P. Pauletto, S. Sartore, G. Scannapieco, A. C. Borrione, A. M. C. Zanellato, M. Tonello et al.
      Pages 149-155

    11. Sodium/Calcium Exchange in Cultured Human Mesangial Cells

      • P. Menè, F. Pugliese, G. A. Cinotti
      Pages 157-165

  4. Membrane Abnormalities: Blood Cell Models

    1. Front Matter

      Pages 167-167
      Download chapter PDF

    2. Relation of Cell Permeability to Salt Sensitivity in Hypertension

      • S. M. Friedman
      Pages 169-174
Back to top

Keywords

About this book

In the last two decades, investigations at the cellular level have progressively gained ground in the context of hypertension research. This choice of approach is due to some extent to the build up of know-how that molecular and cellular biology have been producing at a continuous rate. As the contents list of this volume shows, a large mass of work has been directed to gaining some insight into pathogenetic mechanisms. The pathogenesis of primary hypertension has been progressively categorized as a distinct biological problem, not amenable to the theoretical models that proved successful in understanding the nature of secondary forms of hypertension. At the same time, great efforts have been made to simplify this problem by sorting out, if possible, a few crucial mechanisms from the network of contributory factors in the regulation of blood pressure. The idea that what is to be sought is a primary structural and/or functional fault in arterial muscle has met with widespread acceptance. The strength of this argument lies in the fact that peripheral vascular resistance is increased in all forms of hypertension and, in turn, the diameter of resistance vessels is the dominant factor in the computation of total per­ ipheral resistance. On the basis of this, cardiovascular structural adaptation was proposed as a positive feedback mechanism tending to maintain hypertension, once begun, whatever the initiating factor is.

Editors and Affiliations

  • Istituto di Clinica Medica e Nefrologia, Facolta di Medicina e Chirurgia, Università degli Studi di Parma, Parma, Italy

    Giacomo Bruschi, Alberico Borghetti

Bibliographic Information

  • Book Title: Cellular Aspects of Hypertension

  • Editors: Giacomo Bruschi, Alberico Borghetti

  • DOI: https://doi.org/10.1007/978-3-662-00983-3

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1991

  • Softcover ISBN: 978-3-662-00985-7Published: 15 August 2012

  • eBook ISBN: 978-3-662-00983-3Published: 17 April 2013

  • Edition Number: 1

  • Number of Pages: XII, 271

  • Topics: Cardiology, Anatomy

Publish with us

Policies and ethics

Back to top

Search

Navigation