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Real-Time Monitoring of Cancer Cell Metabolism for Drug Testing

  • Book
  • © 2015

Overview

Authors:
  1. Hamed Alborzinia

    1. Universität Heidelberg, IPMB, Heidelberg, Germany

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  • Publication in the field of natural sciences
  • Includes supplementary material: sn.pub/extras

  • 2704 Accesses

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Table of contents (5 chapters)

  1. Front Matter

    Pages 1-17
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  2. Introduction

    • Hamed Alborzinia
    Pages 7-19

  3. Materials

    • Hamed Alborzinia
    Pages 21-26

  4. Methods

    • Hamed Alborzinia
    Pages 27-32

  5. Results

    • Hamed Alborzinia
    Pages 33-91

  6. Discussion

    • Hamed Alborzinia
    Pages 93-104

  7. Back Matter

    Pages 105-153
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Keywords

About this book

Hamed Alborzinia uses the biosensor chip to monitor the metabolic and morphological changes in cancer cell lines in real time, particularly: (i) real-time measurements of basic cancer cell metabolism of different cancer cell lines; (ii) a detailed timeline of the metabolic response to cisplatin treatment and clear detection of the time span between start of cisplatin treatment and onset of cell death, which reflects the time required for the underlying molecular mechanisms of cell fate decision; (iii) direct functional measurement of the biological activity of a key regulatory protein of cellular metabolism following the kinetic change in respiration upon SIRT3 overexpression; and (iv) the time-resolved impact of several organometallic compounds on cell metabolism and cell morphology, including unexpected and not yet understood highly significant and specific effects on cell-cell interaction and adhesion.

Authors and Affiliations

  • Universität Heidelberg, IPMB, Heidelberg, Germany

    Hamed Alborzinia

About the author

Hamed Alborzinia graduated in veterinary medicine from Shiraz University (Iran) in 2005 and continued in the Ph.D. program, now as post-Doc, with Prof. Dr. Stefan Wölfl at Heidelberg University (IPMB), using bioanalytical techniques in research on cancer cell metabolism.

Bibliographic Information

  • Book Title: Real-Time Monitoring of Cancer Cell Metabolism for Drug Testing

  • Authors: Hamed Alborzinia

  • DOI: https://doi.org/10.1007/978-3-658-10161-9

  • Publisher: Springer Spektrum Wiesbaden

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Fachmedien Wiesbaden 2015

  • Softcover ISBN: 978-3-658-10160-2Published: 10 June 2015

  • eBook ISBN: 978-3-658-10161-9Published: 03 June 2015

  • Edition Number: 1

  • Number of Pages: XIII, 153

  • Number of Illustrations: 32 b/w illustrations

  • Topics: Cancer Research, Pharmacology/Toxicology, Medicinal Chemistry

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