A Guide to Bone Marrow Transplantation

1. Front Matter

   Pages I-X

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2. Introduction

   1. Introduction

      • H. Joachim Deeg, Hans-Georg Klingemann, Gordon L. Phillips

      Pages 1-4

3. Pretransplant Considerations

   1. Front Matter

      Pages 5-5

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   2. Treatment Planning and Timing of Transplantation

      • H. Joachim Deeg, Hans-Georg Klingemann, Gordon L. Phillips

      Pages 7-29

   3. Donor Selection

      • H. Joachim Deeg, Hans-Georg Klingemann, Gordon L. Phillips

      Pages 31-41

   4. Preparation for Marrow Transplantation

      • H. Joachim Deeg, Hans-Georg Klingemann, Gordon L. Phillips

      Pages 43-60

   5. Cost and Availability of Transplantation

      • H. Joachim Deeg, Hans-Georg Klingemann, Gordon L. Phillips

      Pages 61-63

4. Transplant Procedure

   1. Front Matter

      Pages 65-65

      PDF

   2. Conditioning Regimens

      • H. Joachim Deeg, Hans-Georg Klingemann, Gordon L. Phillips

      Pages 67-88

   3. Collection, Processing and Infusion of Marrow

      • H. Joachim Deeg, Hans-Georg Klingemann, Gordon L. Phillips

      Pages 89-101

5. Acute Transplant Related Problems

   1. Front Matter

      Pages 103-103

      PDF

   2. Side Effects of Conditioning Regimens

      • H. Joachim Deeg, Hans-Georg Klingemann, Gordon L. Phillips

      Pages 105-119

   3. Acute Graft-Versus-Host Disease (GVHD)

      • H. Joachim Deeg, Hans-Georg Klingemann, Gordon L. Phillips

      Pages 121-139

   4. Marrow Graft Failure

      • H. Joachim Deeg, Hans-Georg Klingemann, Gordon L. Phillips

      Pages 141-153

   5. Management of Infections

      • H. Joachim Deeg, Hans-Georg Klingemann, Gordon L. Phillips

      Pages 155-174

   6. Interstitial Pneumonitis

      • H. Joachim Deeg, Hans-Georg Klingemann, Gordon L. Phillips

      Pages 175-186

   7. Hepatic Dysfunction

      • H. Joachim Deeg, Hans-Georg Klingemann, Gordon L. Phillips

      Pages 187-203

   8. Kidneys and Urinary Tract

      • H. Joachim Deeg, Hans-Georg Klingemann, Gordon L. Phillips

      Pages 205-212

   9. Central Nervous System

      • H. Joachim Deeg, Hans-Georg Klingemann, Gordon L. Phillips

      Pages 213-225

6. Delayed Transplant Related Problems

   1. Front Matter

      Pages 227-227

      PDF

In 1988 we presented our Guide to Bone Marrow Transplan­ tation. The reception has been enthusiastic and we have re­ ceived a flood of critical comments, suggestions and requests to provide an update in due time. Although several books on marrow transplantation have recently been published, their scope and goal have generally been different. Hence, we have decided to prepare a second edition of the Guide. Our aim was to maintain a short, concise text which never­ theless would incorporate changes that have occurred over the past four or five years. We have streamlined the description of pretransplant considerations, by condensing two sections into one (Treatment Planning and Timing of Transplantation). This also facilitated the review of controversial indications for marrow transplantation, for example in patients with acute myelogenous leukemia in first chemotherapy-induced remission. We have updated the chapter dealing with conditioning regimens and have expanded the section on donor selection, in particular in regard to the current level of tissue typing and the identification of unrelated volunteer donors. In the chapter on collection, processing, and infusion of marrow, we have incorporated recent developments, for example, the use of closed systems for marrow harvesting and processing and the use of solid phase separation of stem cells.

• Knochenmarkstransplantation
• bone marrow
• cancer
• cancer therapy
• care
• central nervous system
• growth
• hematopoietic stem cell transplantation
• leukemia
• nervous system
• oncology
• planning
• rehabilitation
• therapy
• transplantation

• Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, USA

  H. Joachim Deeg

• Department of Medicine, The University of British Columbia, Vancouver, Canada

  Hans-Georg Klingemann

• Division of Hematology, The University of British Columbia, Vancouver, Canada

  Gordon L. Phillips

Policies and ethics