Microtubules

1. Front Matter

   Pages I-XIV

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2. Introduction

   • Pierre Dustin

   Pages 1-4

3. Acknowledgments

   • Pierre Dustin

   Pages 5-7

4. Historical Background

   • Pierre Dustin

   Pages 8-22

5. Structure and Chemistry of Microtubules

   • Pierre Dustin

   Pages 23-78

6. General Physiology of Tubulins and Microtubules

   • Pierre Dustin

   Pages 79-114

7. Microtubule Structures: Centrioles, Basal Bodies, Cilia, Axonemes

   • Pierre Dustin

   Pages 115-166

8. Microtubule Poisons

   • Pierre Dustin

   Pages 167-225

9. Cell Shape

   • Pierre Dustin

   Pages 226-256

10. Cell Movement

    • Pierre Dustin

    Pages 257-283

11. Secretion, Exo- and Endocytosis

    • Pierre Dustin

    Pages 284-307

12. Neurotubules: Neuroplasmic Transport, Neurosecretion, Sensory Cells

    • Pierre Dustin

    Pages 308-339

13. The Role of MT in Mitosis

    • Pierre Dustin

    Pages 340-397

14. Pathology and Medicine

    • Pierre Dustin

    Pages 398-425

15. Outlook

    • Pierre Dustin

    Pages 426-439

16. Back Matter

    Pages 440-454

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The author of this remarkably comprehensive review, PIERRE DUSTIN, has performed an invaluable service in bringing to­ gether in one volume the observations and theory on micro­ tubules that have accumulated over the last fifteen years. He has understood the magnitude of the task from the beginning and has met it thoroughly and, I must say, courageously. From here on, and for many years to come, young investiga­ tors, and some not so young, will have a ready reference as they seek to discover what has been done and remains to be done in achieving a better understanding of these important cell components. Since the early 1960's when it became clear that the fila­ ments (micro tubules) making up the 9 + 2 complex of cilia and flagella were to be found very widely in cells, microtub­ ules have attracted an ever-increasing amount of attention. Now it is known, as reviewed in this volume, that they influ­ ence the morphogenesis of anisometry in the shapes of cells and cell extensions; that they function as frames for the intra­ cellular movement of granules and chromosomes; that they are subject to control in their assembly and disassembly by externally applied substances such as colchicine and cyclic AMP; and that they display abnormalities in their numbers and orientations in transformed (malignant) cells, to mention only a few of their several functions.

• Cellular activity
• Colchicine
• Endoplasmatisches Reticulum
• Mikrotubuli
• attention

• Laboratoires d’Anatomie Pathologique et de Microscopie Electronique, Université Libre de Bruxelles, Bruxelles, Belgium

  Pierre Dustin

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