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The Ribosome

  • Book
  • © 1969

Overview

Authors:
  1. A. S. Spirin

    1. A. N. Bakh Institute of Biochemistry and Institute of Protein Research, Academy of Sciences of the USSR, Moscow, USSR

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  2. L. P. Gavrilova

    1. A. N. Bakh Institute of Biochemistry and Institute of Protein Research, Academy of Sciences of the USSR, Moscow, USSR

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Table of contents (9 chapters)

  1. Front Matter

    Pages I-X
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  2. Fundamental Introduction

    1. Fundamental Introduction

      • A. S. Spirin, L. P. Gavrilova
      Pages 1-17

  3. Structure of the Ribosome

    1. Physical Properties and Chemical Composition of the Ribosomes

      • A. S. Spirin, L. P. Gavrilova
      Pages 18-34

    2. Ribosomal RNA

      • A. S. Spirin, L. P. Gavrilova
      Pages 34-54

    3. Ribosomal Proteins

      • A. S. Spirin, L. P. Gavrilova
      Pages 54-63

    4. Structural Transformations of Ribosomes

      • A. S. Spirin, L. P. Gavrilova
      Pages 63-77

  4. Functioning of the Ribosome

    1. Components of the Protein-Synthesizing System

      • A. S. Spirin, L. P. Gavrilova
      Pages 78-88

    2. Association of the Ribosome with Components of the Protein-Synthesizing System

      • A. S. Spirin, L. P. Gavrilova
      Pages 88-103

    3. Stages of Translation

      • A. S. Spirin, L. P. Gavrilova
      Pages 104-133

    4. Appendix: On the Mechanism of the Action of Certain Antibiotics

      • A. S. Spirin, L. P. Gavrilova
      Pages 133-140

  5. Back Matter

    Pages 141-164
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Keywords

About this book

This monograph is neither a historical outline of the development of the concepts of protein biosynthesis and the structure and functions of the ribosomes, nor an exhaustive survey of the literature on these questions. The monograph is based upon an analysis of the modern trends in this field. The purpose of the monograph was to formulate more or less generalized representations of the structure and" function of the ribosome, as we envision it at the present day. It may be that this attempt is premature for a number of reasons, and the concepts outlined here will very soon be revised. Nonetheless, despite this risk, we believe it to be advisable to undertake this attempt for the following reasons: firstly, the undertaken analysis could aid in the comprehension of the substantial mass of extremely scattered experimental data on the ribosomes presently available; secondly, in any event, even if most of the concepts outlined rapidly become obselete, they can still serve as a stimulus for a whole series of experiments; and thirdly, we hope that some of the concepts outlined will still remain essentially correct and relatively stable. In view of the aforementioned, we should make the following reservations. First of all, we made no attempt to cite all the literature on the problems discussed, but considered it sufficient to illustrate the various premises with one or several sample references.

Authors and Affiliations

  • A. N. Bakh Institute of Biochemistry and Institute of Protein Research, Academy of Sciences of the USSR, Moscow, USSR

    A. S. Spirin, L. P. Gavrilova

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