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Optical Activity of Proteins and Other Macromolecules

  • Book
  • © 1973

Overview

Authors:
  1. B. Jirgensons

    1. M. D. Anderson Hospital and Tumor Institute, Department of Biochemistry, The University of Texas, Houston, USA

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Table of contents (12 chapters)

  1. Front Matter

    Pages I-IX
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  2. The Realm of Proteins. Structural Features. The Phenomenon of Optical Activity. Historical Highlights

    • B. Jirgensons
    Pages 1-9

  3. The Phenomena of Optical Activity. Terms and Definitions. Theoretical Considerations. The Drude and Moffitt Equations

    • B. Jirgensons
    Pages 10-27

  4. Polarimeters and Spectropolarimeters. The Measurement of Optical Activity

    • B. Jirgensons
    Pages 28-46

  5. Optical Activity of Amino Acids, Peptides, and Proteins

    • B. Jirgensons
    Pages 47-56

  6. The Optical Rotatory Dispersion of Polyamino Acids and Proteins. Measurements in the Visible and Near Ultraviolet Spectral Zones

    • B. Jirgensons
    Pages 57-65

  7. The Far Ultraviolet Cotton Effects of Synthetic Polyamino Acids

    • B. Jirgensons
    Pages 66-74

  8. The Cotton Effects and Conformation of Proteins

    • B. Jirgensons
    Pages 75-98

  9. Cotton Effects and Conformation of Nonhelical Proteins

    • B. Jirgensons
    Pages 99-123

  10. Optical Activity of Structural Proteins

    • B. Jirgensons
    Pages 124-133

  11. Optical Activity of Nucleoproteins and Histones

    • B. Jirgensons
    Pages 134-145

  12. Optical Activity of Glycoproteins and Lipoproteins

    • B. Jirgensons
    Pages 146-157

  13. Concluding Remarks

    • B. Jirgensons
    Pages 158-159

  14. Back Matter

    Pages 161-202
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Keywords

About this book

The application of circular dichroism (CD) to various problems involving con­ formation of proteins and other biopolymers is emphasized in this revised and enlarged second edition. The usefulness of CD and ORD in helping to solve structural prob­ lems is demonstrated by many examples, and the most essential data are tabulated. The author is sincerely grateful to the editors of the series Molecular Biology, Bio­ chemistry and Biophysics, especially to Professor GEORG F. SPRINGER, M.D., for their interest in this edition, as well as to the many reviewers for their constructive criticism of the first edition of this book. Our previously unpublished work reported in this second edition was supported in part by grants from the R. A. Welch Foundation (grant G-051) and U.S. Public Health Service (grant CA-01785). Houston, September 1973 B. JIRGENSONS Preface to the First Edition Great advances have been made in the application of physical methods in the study of the structure of proteins and other biological macromolecules. Optical rotatory dispersion has been successful in solving structural problems, and a vast amount of literature has accumulated on this subject. Several review articles appeared between 1961 and 1965, but significant progress has been made since 1965. Important new studies, especially on the Cotton effects in the far ultraviolet spectrum, have rendered many previous publications obsolete so that a concise monograph should be useful at this time.

Authors and Affiliations

  • M. D. Anderson Hospital and Tumor Institute, Department of Biochemistry, The University of Texas, Houston, USA

    B. Jirgensons

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