Nucleic Acids in Immunology

1. Front Matter

   Pages i-xvii

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2. Oligo- and Polynucleotides as Haptens (Part I)

   1. Front Matter

      Pages 1-1

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   2. Reading the Helix Backwards

      • Michael Heidelberger

      Pages 3-4

   3. Methylated Bovine Serum Albumin as a Carrier for Oligo- and Poly-Nucleotides

      • Otto J. Plescia, Werner Braun, Saverio Imperato, Elisa Cora-Block, Lydie Jaroskova, Connie Schimbor

      Pages 5-17

   4. The Production of Antibodies to Mononucleotides, Oligonucleotides, and DNA

      • C. W. Parker, M. J. Halloran

      Pages 18-31

   5. Specific Antibodies to Polynucleotide Complexes and their Reaction with Nucleic Acids: Importance of the Secondary Structure of the Antigen

      • F. Lacour, A. M. Michelson, E. Nahon

      Pages 32-46

   6. Specificity in the Reaction between Anti-Pyrimidine Nucleoside Antibodies and DNA

      • A. J. Garro, B. F. Erlanger, S. M. Beiser

      Pages 47-57

   7. Antibodies to the Terminal Moieties of Guanine Mononucleotides and Guanine-Containing Dinucleotides

      • Helen Van Vunakis, Edna Seaman, Lawrence Levine

      Pages 58-66

3. Oligo- and Polynucleotides as Haptens (Part II)

   1. Front Matter

      Pages 77-77

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   2. Formation and Isolation of Antibodies Specific for Nucleotides

      • P. Grabar, S. Avrameas, B. Taudou, J. C. Salomon

      Pages 79-87

   3. The Reaction of Anti-Deoxyribonucleic Acid Sera with Nucleoside and Nucleotide Conjugates

      • Sergio Estrada-Parra, Eugenia Olguin-Palacios

      Pages 88-97

   4. The Various Types of DNA Antibodies in Lupus Sera

      • M. Seligmann, R. Arana

      Pages 98-113

   5. DNA and Nucleoprotein Determinants for Systemic Lupus Erythematosus Sera

      • B. David Stollar

      Pages 114-124

   6. Cellular Phases of the Immune Response Following Immunization with Mammalian and Bacterial Ribosomes

      • M. C. Dodd, N. J. Bigley

      Pages 125-146

4. Use of Nucleic Acid-Specific Antibodies

   1. Front Matter

      Pages 155-155

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   2. Immunological Evidence for the Existence of Thymine Dimers in Ultraviolet Irradiated DNA

      • Edna Seaman, Lawrence Levine, Helen Van Vunakis

      Pages 157-164

   3. Immunological Evidence for the Identity of a Photoproduct Formed during Photooxidation of DNA with Methylene Blue, Rose Bengal, Thionin, and Acridine Orange

      • Lawrence Levine, Edna Seaman, Helen Van Vunakis

      Pages 165-173

   4. Use of Anti-RNA Antibodies in the Study of the Structure of Polynucleotides and Ribosomal Particles

      • Jacques Panijel

      Pages 174-200

   5. Inhibition of Bacterial Transformation by Nucleic Acid-Specific Antibodies

      • Robert Erickson, Werner Braun, Otto J. Plescia, Zbigniew Kwiatkowski

      Pages 201-221

   6. Effects of Anti-Hapten Antibodies on the Biological Activities of Nucleic Acids

      • S. W. Tanenbaum, Meryl H. Karol

      Pages 222-247

Two fields have played a leading role in biomedical research in recent years, the biochemistry of nucleic acids and immunology. Yet, with the exception of those aspects which have been concerned with antibody synthesis as an example of protein synthesis, there was until recently a lack of direct association between the two fields. Until quite recently the antigenicity of nucleic acids was still in doubt and indeed represented a controversial subject. Also, the exact role of the various nucleic acids in various stages of antibody synthesis was uncertain. These skepticisms and uncertainties disappeared rapidly in the last few years. New experi­ mental approaches brought the realization that nucleic acids, under appropriate conditions, are indeed immunogenic, and that the resulting antibodies can furnish new tools for the exploration of the mplecular structure of the all-important family of nucleic acid molecules. ' At the same time, the recognition of the antigenicity of nucleic acids brought a new level of understanding to certain auto-immune diseases and pro­ vided new material for the exploration of the role of a carrier in immune responses. Side by side with this development was the almost explosive development of new experimental approaches and new ideas pertaining to the problem of antibody formation. Nucleic acids in their various forms were recognized as playing an expected major role in the activation of antibody-forming cells. Perhaps less to be expected was the role they can playas non-specific stimulators of antibody formation.

• Antigen
• biochemistry
• biomedical research
• chemistry
• diseases
• immune response
• immunology
• protein

• Institute of Microbiology, Rutgers, The State University, USA

  Otto J. Plescia, Werner Braun

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