Colorectal Cancer

1. Front Matter

   Pages I-XII

   PDF

2. Epidemiology

   1. Front Matter

      Pages 1-1

      PDF

   2. Geographic Epidemiology of Colorectal Cancer: The Role of Dietary Fat

      • G. N. Stemmermann

      Pages 3-23

   3. Genetic Predisposition to Colorectal Cancer

      • D. G. Harnden

      Pages 24-43

   4. Acquired Conditions of Increased Risk of Colorectal Cancer

      • R. R. Frentzel-Beyme

      Pages 44-60

   5. Inflammatory Bowel Disease and Colorectal Cancer

      • A. J. Greenstein, D. B. Sachar

      Pages 61-72

   6. Biomarkers in the Identification of High-Risk Groups

      • M. Lipkin

      Pages 73-85

3. Dietary Factors in the Pathophysiology of Colorectal Cancer

   1. Front Matter

      Pages 87-87

      PDF

   2. Dietary Fat and Colorectal Cancer: Experimental Evidence for Tumor Promotion

      • P. M. Newberne, S. Sahaphong

      Pages 89-111

   3. Cholesterol, Neutral Sterols and Colorectal Cancer

      • J. P. Cruse

      Pages 112-124

   4. The Role of Bile Acids in Colorectal Carcinogenesis

      • B. I. Cohen, E. E. Deschner

      Pages 125-138

   5. Dietary Fiber, Fiber-Containing Foods, and Colon Cancer Risk

      • L. R. Jacobs

      Pages 139-159

   6. Colorectal Bacteria in Colorectal Carcinogenesis

      • M. J. Hill

      Pages 160-176

   7. Ethanol and Colorectal Carcinogenesis

      • H. K. Seitz, U. A. Simanowski

      Pages 177-189

4. Pathophysiologic Mechanisms in Colorectal Carcinogenesis

   1. Front Matter

      Pages 191-191

      PDF

   2. Environmental and Dietary Carcinogens Possibly Related to Colorectal Cancer

      • M. J. Wargovich, P. J. Hu

      Pages 193-201

   3. Experimental Models of Colorectal Carcinogenesis

      • S. R. Hamilton

      Pages 202-216

   4. Colonic Microsomal Enzymes and Their Role in Colorectal Carcinogenesis

      • H. W. Strobel, D. K. Hammond, T. B. White

      Pages 217-224

   5. Mucosal Cellular Regeneration and Colorectal Carcinogenesis

      • U. A. Simanowski, N. A. Wright, H. K. Seitz

      Pages 225-236

   6. The Control of Cell Proliferation in Colonic Epithelium

      • N. A. Wright

      Pages 237-243

The past 20 years have seen a surge of research into colorectal cancer, which is a reflection of the need to improve our methods of treating patients suffering from this increasingly common form of cancer. Greater knowledge of the basic mechanisms involved in colorectal carcinogenesis is an essential prerequisite to improvements in cancer prevention. In this volume the editors have brought together an impressive list of experts to cover the epidemiology, pathophysiology, morphology and basis for new diagnostic and therapeutic approaches to early detection and prevention. This broad scientific approach provides the reader with up-to-date review of our current state of knowl­ edge of colorectal carcinogenesis and indicates how this information can be used to generate more research and create new opportunities for diagnosis and treatment. This is a book of knowledge and ideas, some of them still at the stage of theoretical interest, but others with practical potential for the care of patients. I recommend it to those who have a research interest in colorectal carcinogenesis, as well as to readers who wish to know just how far medical scientists have progressed in their efforts to achieve the ideal of cancer prevention.

• cancer
• cancer prevention
• carcinogenesis
• carcinoma
• cell
• colon
• colorectal cancer
• pathogenesis
• pathophysiology
• prevention
• tumor
• hepatology

• Innere Medizin IV (Gastroenterologie), Medizinische Universitätsklinik, Heidelberg 1, Germany

  Helmut Karl Seitz, Ulrich A. Simanowski

• Department of Histopathology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK

  Nicholas A. Wright

Policies and ethics