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Arteriosclerosis

New Insights into Pathogenetic Mechanisms and Prevention

  • Conference proceedings
  • © 1994

Overview

Editors:
  1. H. Just

    1. Abt. Innere Medizin III, Medizinische Universitätsklinik, Freiburg, Deutschland

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  2. W. Hort

    1. Pathologisches Institut, Heinrich-Heine-Universität, Düsseldorf, Deutschland

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  3. A. M. Zeiher

    1. Abt. Innere Medizin III, Medizinische Universitätsklinik, Freiburg, Deutschland

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Table of contents (16 papers)

  1. Front Matter

    Pages I-X
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  2. Arteriosclerosis: Its morphology in the past and today

    • W. Hort
    Pages 1-15

  3. Changes in components and structure of atherosclerotic lesions developing from childhood to middle age in coronary arteries

    • Herbert C. Stary
    Pages 17-32

  4. Lipid and cellular constituents of unstable human aortic plaques

    • M. J. Davies, N. Woolf, P. Rowles, P. D. Richardson
    Pages 33-39

  5. Immunological control mechanisms in plaque formation

    • G. K. Hansson
    Pages 41-46

  6. Proliferation versus atrophy — the ambivalent role of smooth muscle cells in human atherosclerosis

    • H.-E. Schaefer
    Pages 47-58

  7. Extracellular matrix degrading metalloproteinases in the pathogenesis of arteriosclerosis

    • Andrew C. Newby, K. M. Southgate, M. Davies
    Pages 59-70

  8. Vascular renin-angiotensin-system, endothelial function and atherosclerosis?

    • J. Holtz, R. M. Goetz
    Pages 71-86

  9. Endothelial dysfunction in atherosclerosis

    • David G. Harrison
    Pages 87-102

  10. New determinants of the uptake of atherogenic plasma proteins by arteries

    • G. V. R. Born
    Pages 103-106

  11. Hyperlipidemic endothelial injury and angiogenesis

    • Philip D. Henry
    Pages 107-114

  12. Assessment of endothelial modulation of coronary vasomotor tone: Insights into a fundamental functional disturbance in vascular biology of atherosclerosis

    • A. M. Zeiher, V. Schächinger, B. Saurbier, H. Just
    Pages 115-128

  13. In vitro assessment of luminal dimensions of coronary arteries by intravascular ultrasound with and without application of echogenic contrast dye

    • Karl M. Schmid, W. Voelker, J. Mewald, H.-J. Paul, M. Wehrmann, B. Bültmann et al.
    Pages 129-135

  14. Therapeutic approaches to the control of coronary atherosclerosis

    • W. G. Nayler
    Pages 137-143

  15. Role of calcium in arteriosclerosis — Experimental evaluation of antiarteriosclerotic potencies of Ca antagonists

    • G. Fleckenstein-Grün, F. Thimm, M. Frey, A. Czirfusz
    Pages 145-159

  16. Role of calcium antagonists in progression of arteriosclerosis. Evidence from animal experiments and clinical experience

    • H. Just, M. Frey
    Pages 161-184

  17. Lipid-lowering therapy — Implications for the prevention of atherosclerosis

    • G. Schmitz, K. J. Lackner
    Pages 185-198

  18. Back Matter

    Pages 199-202
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Keywords

About this book

A vast literature has been concerned with arteriosclerosis and yet, many aspects of pathogenesis and of the mechanism of development of the arteriosclerotic vascular lesion remain only poorly understood. In recent years, our knowledge of the earliest stages of arteriosclerosis have greatly improved. By now, we have learned to relate morphologic changes to disturbances in function. It has been of particular impor­ tance that components of the arterial wall could be analyzed in regard to dysfunction, for example, in the endothelium or the vascular smooth muscle. The interaction of the different morphological components of the vascular wall could thus be much bet­ ter understood. Likewise, the interaction between the arterial wall and the flowing blood could be much better described, including the intimate relationship between platelets and the endothelium, the coagulation system and the endothelium, the granulocytes and the endothelial cell layer, as well as processes of migration of blood cells into the subendothelial space. The recognition of functional and morphological disturbance has attained clinical significance not only because the arteriosclerotic diseases have quantitatively reached the dimensions of an epidemic, that is, of a magnitude never been witnessed. It is also because of the development of new drugs that interfere with the atherogenic process and thereby prevent the development of the disease or halt its progression. It is also becoming increasingly possible to inhibit the occurrence of complications in existing arteriosclerotic lesions in manifest disease, i. e.

Editors and Affiliations

  • Abt. Innere Medizin III, Medizinische Universitätsklinik, Freiburg, Deutschland

    H. Just, A. M. Zeiher

  • Pathologisches Institut, Heinrich-Heine-Universität, Düsseldorf, Deutschland

    W. Hort

Bibliographic Information

  • Book Title: Arteriosclerosis

  • Book Subtitle: New Insights into Pathogenetic Mechanisms and Prevention

  • Editors: H. Just, W. Hort, A. M. Zeiher

  • DOI: https://doi.org/10.1007/978-3-642-85660-0

  • Publisher: Steinkopff Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Dr. Dietrich Steinkopff Verlag GmbH & Co. KG, Darmstadt 1994

  • Softcover ISBN: 978-3-642-85662-4Published: 17 February 2012

  • eBook ISBN: 978-3-642-85660-0Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: X, 202

  • Topics: Cardiology, Human Physiology

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