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Transgenic Models of Human Viral and Immunological Disease

  • Book
  • © 1996

Overview

Editors:
  1. Francis V. Chisari

    1. Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, USA
      Division of Experimental Pathology, The Scripps Research Institute, La Jolla, USA

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  2. Michael B. A. Oldstone

    1. Department of Neuropharmacology, The Scripps Research Institute, USA
      Division of Virology, The Scripps Research Institute, USA

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Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 206)

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Table of contents (16 chapters)

  1. Front Matter

    Pages I-XI
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  2. Cytotoxic T Cell Effector and Memory Function in Viral Immunity

    • P. C. Doherty
    Pages 1-14

  3. Transgenic Mouse Models of Experimental Autoimmune Encephalomyelitis

    • D. M. Zaller, V. S. Sloan
    Pages 15-31

  4. The Contribution of Insulitis to Diabetes Development in Tumor Necrosis Factor Transgenic Mice

    • R. A. Flavell, A. Kratz, N. H. Ruddle
    Pages 33-50

  5. Influence of T Lymphocytes and Major Histocompatibility Complex Class II Genes on Diabetes Susceptibility in the NOD Mouse

    • R. M. Slattery, J. F. A. P. Miller
    Pages 51-66

  6. Virus-Induced Autoimmune Disease: Transgenic Approach to Mimic Insulin-Dependent Diabetes Mellitus and Multiple Sclerosis

    • M. B. A. Oldstone, M. von Herrath, C. F. Evans, M. S. Horwitz
    Pages 67-83

  7. Role of HLA-B27 in Spondyloarthropathies

    • S. D. Khare, H. S. Luthra, C. S. David
    Pages 85-100

  8. The Influence of Cytokines on the Central Nervous System of Transgenic Mice

    • K. Geiger, N. Sarvetnick
    Pages 101-117

  9. Mx Transgenic Mice — Animal Models of Health

    • H. Arnheiter, M. Frese, R. Kambadur, E. Meier, O. Haller
    Pages 119-147

  10. Hepatitis B Virus Transgenic Mice: Models of Viral Immunobiology and Pathogenesis

    • F. V. Chisari
    Pages 149-173

  11. Transgenic Models of HTLV-I Mediated Disease and Latency

    • M. Nerenberg, X. Xu, D. A. Brown
    Pages 175-196

  12. Transgenic Models of Human Immunodeficiency Virus Type-1

    • P. E. Klotman, A. L. Notkins
    Pages 197-222

  13. Transgenic Models in the Study of AIDS Dementia Complex

    • S. M. Toggas, L. Mucke
    Pages 223-241

  14. Regulation of Expression and Pathogenic Potential of Human Foamy Virus In Vitro and in Transgenic Mice

    • A. Aguzzi, S. Marino, R. Tschopp, A. Rethwilm
    Pages 243-273

  15. Transgenetics of Prion Diseases

    • S. B. Prusiner
    Pages 275-304

  16. Poliovirus Biology and Pathogenesis

    • V. R. Racaniello, R. Ren
    Pages 305-325

  17. Safety Requirements for Maintenance and Distribution of Transgenic Mice Susceptible to Human Viruses: The Example of Poliovirus-Susceptible Transgenic Mice

    • Y. Ghendon, P.-H. Lambert
    Pages 327-340

  18. Back Matter

    Pages 341-348
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Keywords

About this book

Most diseases are multifactoral. Transgenic technology permits gene(s) of interest to be expressed in a small manipulatable laboratory animal model. By this process, murine models of human infections can be developed and studied; effects of cytokines in vivo, focally expressed in unique cells can be established and manipulated, and a variety of autoimmune disorders, mimicking human disease can be constructed. In this volume, these approaches for study of human immunodeficiency virus, hepatitis virus, viruses causing tumors and chronic degenerative disorders are described. Also included are chapters of transgenic models of autoimmune disorders like diabetes, systemic lupus and ankylosing spondylitis.

Editors and Affiliations

  • Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, USA

    Francis V. Chisari

  • Division of Experimental Pathology, The Scripps Research Institute, La Jolla, USA

    Francis V. Chisari

  • Department of Neuropharmacology, The Scripps Research Institute, USA

    Michael B. A. Oldstone

  • Division of Virology, The Scripps Research Institute, USA

    Michael B. A. Oldstone

Bibliographic Information

  • Book Title: Transgenic Models of Human Viral and Immunological Disease

  • Editors: Francis V. Chisari, Michael B. A. Oldstone

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-85208-4

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1996

  • Softcover ISBN: 978-3-642-85210-7Published: 13 November 2013

  • eBook ISBN: 978-3-642-85208-4Published: 06 December 2012

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: XI, 348

  • Topics: Immunology, Neurosciences, Cell Biology

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