Skip to main content
  • Book
  • © 1996

Transgenic Models of Human Viral and Immunological Disease

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 206)

Buy it now

Buying options

eBook USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

This is a preview of subscription content, log in via an institution to check for access.

Table of contents (16 chapters)

  1. Front Matter

    Pages I-XI
  2. Role of HLA-B27 in Spondyloarthropathies

    • S. D. Khare, H. S. Luthra, C. S. David
    Pages 85-100
  3. Mx Transgenic Mice — Animal Models of Health

    • H. Arnheiter, M. Frese, R. Kambadur, E. Meier, O. Haller
    Pages 119-147
  4. Transgenic Models of HTLV-I Mediated Disease and Latency

    • M. Nerenberg, X. Xu, D. A. Brown
    Pages 175-196
  5. Transgenic Models of Human Immunodeficiency Virus Type-1

    • P. E. Klotman, A. L. Notkins
    Pages 197-222
  6. Transgenic Models in the Study of AIDS Dementia Complex

    • S. M. Toggas, L. Mucke
    Pages 223-241
  7. Transgenetics of Prion Diseases

    • S. B. Prusiner
    Pages 275-304
  8. Poliovirus Biology and Pathogenesis

    • V. R. Racaniello, R. Ren
    Pages 305-325
  9. Back Matter

    Pages 341-348

About this book

Most diseases are multifactoral. Transgenic technology permits gene(s) of interest to be expressed in a small manipulatable laboratory animal model. By this process, murine models of human infections can be developed and studied; effects of cytokines in vivo, focally expressed in unique cells can be established and manipulated, and a variety of autoimmune disorders, mimicking human disease can be constructed. In this volume, these approaches for study of human immunodeficiency virus, hepatitis virus, viruses causing tumors and chronic degenerative disorders are described. Also included are chapters of transgenic models of autoimmune disorders like diabetes, systemic lupus and ankylosing spondylitis.

Editors and Affiliations

  • Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, USA

    Francis V. Chisari

  • Division of Experimental Pathology, The Scripps Research Institute, La Jolla, USA

    Francis V. Chisari

  • Department of Neuropharmacology, The Scripps Research Institute, USA

    Michael B. A. Oldstone

  • Division of Virology, The Scripps Research Institute, USA

    Michael B. A. Oldstone

Bibliographic Information

  • Book Title: Transgenic Models of Human Viral and Immunological Disease

  • Editors: Francis V. Chisari, Michael B. A. Oldstone

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-85208-4

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1996

  • Softcover ISBN: 978-3-642-85210-7Published: 13 November 2013

  • eBook ISBN: 978-3-642-85208-4Published: 06 December 2012

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: XI, 348

  • Topics: Immunology, Neurosciences, Cell Biology

Buy it now

Buying options

eBook USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access