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Familial and Hereditary Tumors

  • Book
  • © 1994

Overview

Authors:
  1. M. Ponz Leon

    1. Istituto di Patologia Medica Policlinico, Università degli Studi di Modena, Modena, Italy

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Part of the book series: Recent Results in Cancer Research (RECENTCANCER, volume 136)

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Table of contents (22 chapters)

  1. Front Matter

    Pages I-X
    Download chapter PDF

  2. Introduction

    • M. Ponz de Leon
    Pages 1-8

  3. Genetic Aspects of Diseases: Categories of Genetic Disorders

    • M. Ponz de Leon
    Pages 9-23

  4. Biomarkers of Increased Susceptibility to Cancer

    • M. Ponz de Leon
    Pages 24-34

  5. Oncogenes and Tumor Suppressor Genes

    • M. Ponz de Leon
    Pages 35-47

  6. Genetic Factors in Solid Tumors of Childhood

    • M. Ponz de Leon
    Pages 48-58

  7. Retinoblastoma

    • M. Ponz de Leon
    Pages 59-67

  8. Multiple Endocrine Neoplasia

    • M. Ponz de Leon
    Pages 68-83

  9. Hereditary Tumors of the Nervous System

    • M. Ponz de Leon
    Pages 84-93

  10. Hereditary Melanoma and Dysplastic Nevus Syndrome

    • M. Ponz de Leon
    Pages 94-109

  11. Hereditary and Familial Breast Tumors

    • M. Ponz de Leon
    Pages 110-132

  12. Hereditary and Familial Ovarian Cancer

    • M. Ponz de Leon
    Pages 133-145

  13. Genetic Factors in Lung Cancer

    • M. Ponz de Leon
    Pages 146-161

  14. Genetic Factors in Precancerous Lesions and Cancer of the Esophagus

    • M. Ponz de Leon
    Pages 162-178

  15. Genetic Predisposition and Environmental Factors in Gastric Carcinoma

    • M. Ponz de Leon
    Pages 179-202

  16. Hereditary and Familial Colorectal Cancer

    • M. Ponz de Leon
    Pages 203-237

  17. Hereditary Gastrointestinal Polyposis Syndromes

    • M. Ponz de Leon
    Pages 238-264

  18. Familial Aspects in Carcinoma of the Pancreas

    • M. Ponz de Leon
    Pages 265-274

  19. Li-Fraumeni Syndrome

    • M. Ponz de Leon
    Pages 275-286

  20. Genetic Factors in Leukemia and Lymphoma

    • M. Ponz de Leon
    Pages 287-305
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Keywords

About this book

For many years the etiology of human tumors has almost exclusively been attributed to environmental factors, which seemed to be involved not only in the induction of neo­ plasms but also in other phases of tumorigenesis. Cigarette smoking and alcohol are the two best known examples of factors related to our modern lifestyle which have been implicated in the development of cancer of various organs. From the 1960s onward, the pioneer work of a few investigators clearly showed that hereditary factors were not only related to rare neoplasms, but could also be respon­ sible for the occurrence of a sizeable fraction of tumors that do not usually show features of inheritance (as in the case of breast or colorectal cancer). Thus, the idea that some common human malignancies could be transmitted from one generation to another with features of mendelian gene­ tics became more and more evident. In addition, the verit­ able explosion of molecular biology in the last 15 years has made a further and substantial contribution to the emerging role of genetics in biomedical research and particularly in cancer.

Authors and Affiliations

  • Istituto di Patologia Medica Policlinico, Università degli Studi di Modena, Modena, Italy

    M. Ponz Leon

Bibliographic Information

  • Book Title: Familial and Hereditary Tumors

  • Authors: M. Ponz Leon

  • Series Title: Recent Results in Cancer Research

  • DOI: https://doi.org/10.1007/978-3-642-85076-9

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1994

  • Softcover ISBN: 978-3-642-85078-3Published: 22 November 2011

  • eBook ISBN: 978-3-642-85076-9Published: 06 December 2012

  • Series ISSN: 0080-0015

  • Series E-ISSN: 2197-6767

  • Edition Number: 1

  • Number of Pages: X, 349

  • Number of Illustrations: 7 b/w illustrations

  • Topics: Oncology

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