Pathogenicity of Human Herpesviruses due to Specific Pathogenicity Genes

1. Front Matter

   Pages I-XVI

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2. Herpes Simplex Virus

   1. Front Matter

      Pages 1-1

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   2. Genes Involved in Entry

      1. Entry of Herpes Simplex Virus Type 1 into Cells — Early Steps in Virus Pathogenicity

         • Yechiel Becker, Eynat Tabor, Yael Asher, Mirta Grifman, Yosef Kleinman, Avner Yayon

         Pages 3-20

      2. Neomycin and Herpes Simplex Virus Receptor Binding: The Role of Glycoprotein C

         • Anne M. Øyan, Lars Haarr, Joseph C. Glorioso, Karen E. Dolter, Howard S. Marsden, Clyde S. Crumpacker et al.

         Pages 21-32

      3. Pathogenicity of Glycoprotein C-Negative Herpes Simplex Virus Type 1 in Herpetic Keratitis

         • Yasushi Toh, Yasufumi Hidaka, Yuji Kumano, Hiroko Minagawa, Ryoichi Mori

         Pages 33-42

      4. Structure and Function of Glycoprotein D of Herpes Simplex Virus

         • R. J. Eisenberg, D. Lone, D. L. Sodora, H.-Y. Chiang, W. C. Wilcox, W. R. Abrams et al.

         Pages 43-65

   3. Genes Coding for Enzymes

      1. The Role of Herpes Simplex Virus Thymidine Kinase Expression in Pathogenesis and Latency

         • Richard B. Tenser

         Pages 68-86

      2. Herpes Simplex Virus Type 1 DNA Polymerase: Eukaryotic Model Enzyme and Principal Target of Antiviral Therapy

         • Charles W. Knopf, Reiner Strick

         Pages 87-135

      3. Ribonucleotide Reductase and the Ocular Virulence of Herpes Simplex Virus Type 1

         • Curtis R. Brandt, Randall Kintner, Robert J. Visalli, Anne M. Pumfery

         Pages 136-150

      4. Ribonucleotide Reductase Gene in Herpes Simplex Virus Type 2 and Virus Pathogenicity

         • Laure Aurelian

         Pages 151-167

   4. Genes Related to Intraperitoneal Pathogenicity

      1. Effect of Herpes Simplex Virus Type 1 <i>UL41</i> Gene Product on <i>mdr-1</i> Gene-mRNA in Infected Adrenal Glands

         • Michal Moyal, Yechiel Becker

         Pages 170-176

      2. Pathogenicity and Latency of Herpes Simplex Virus in the Animal Model System Tree Shrew

         • Angela Rösen-Wolff, Roland Kehm, Eva Lorentzen, Wolfram Lamade, Gholamreza Darai

         Pages 177-202

      3. Computer Analysis of the Protein Coded by Herpes Simplex Virus Type 1 <i>UL56</i> Gene

         • Mirta Grifman, Yechiel Becker

         Pages 203-207

   5. Genes and Latency and Intracerebral Pathogenicity

      1. The Herpes Simplex Type 1 Virus Latency Gene

         • Edward K. Wagner

         Pages 210-221

      2. Neurovirulence of Herpes Simplex Virus Type 1 Accessory Gene Mutants

         • Myron Levine, David J. Fink, Ramesh Ramakrishnan, Prashant Desai, William F. Goins, Joseph C. Glorioso

         Pages 222-237

      3. Herpes Simplex Virus Latency and Immediate Early Gene Repression by the Cellular Octamer-Binding Protein Oct-2

         • David S. Latchman

         Pages 238-252

      4. The Cell Fusion Protein Gene (<i>UL53</i>) of Herpes Simplex Virus Type 1 — A Pathogenicity Gene

         • Michal Moyal, Yechiel Becker

         Pages 253-260

   6. Genes and Latency and Intracerebral Pathogenicity

      1. Role of Langerhans Cells and Other Dendritic Cells in the Pathogenesis of Herpes Simplex Virus Type 1 Infection

         • Eli Sprecher, Yechiel Becker

         Pages 262-280

3. Epstein Barr Virus

   1. Front Matter

      Pages 281-281

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   2. Gene Expression in Burkitt’s Lymphoma Cells

      • Marc Jacquemin, Alison J. Sinclair, Paul J. Farrell

      Pages 283-297

Six members of the Herpesviridae family are human pathogens, including herpes and 2 (HSV-I and 2), Epstein-Barr virus (EBV), varicella zoster simplex virus I virus (VZV), human cytomegalovirus (HCMV), and human herpesvirus 6 (HHV 6). Each of these viruses is capable of causing distinct diseases of varying severity in children, young adults, and the aged. The diseases range from infection of epithelial tissue to the infection of internal organs and white blood cells. A common feature of the six pathogenic human herpesviruses is their ability to latently infect different cell types in which the viral DNA is not integrated and is unable to express its pathogenicity. Reactivation of the herpesviruses is a result of cellular processes which reactivate viral genes, leading to virus progeny and to signs of infection. Due to their ability to become latent after initial infection, once the pathogenic herpesviruses infect children they are maintained throughout life, having the potential of cause various diseases upon reactivation.

• Cytomegalovirus
• Epstein Barr Virus
• Herpes Simplex Virus
• Herpesvirus
• Human Herpesvirus-6
• Varicella Zoster Virus
• Viruses
• biology
• gene
• infection
• molecular biology
• tissue
• vaccine
• virus

• Department of Molecular Virology, Institute of Microbiology, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel

  Yechiel Becker

• Institut für Medizinische Virologie, Universität Heidelberg, Heidelberg, Germany

  Gholamreza Darai

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