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Current Topics in Clinical Radiobiology of Tumors

  • Book
  • © 1993

Overview

Editors:
  1. Hans-Peter Beck-Bornholdt

    1. Institut für Biophysik und Strahlenbiologie, Universität Hamburg, Hamburg, Germany

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Part of the book series: Medical Radiology (MEDRAD)

Part of the book sub series: Radiation Oncology (Med Radiol Radiat Oncol)

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Table of contents (11 chapters)

  1. Front Matter

    Pages I-IX
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  2. Accelerated Fractionation

    • H. D. Thames, L. J. Peters, K. K. Ang
    Pages 1-10

  3. Time-Dose Relationships for Human Tumors: Estimation from Nonrandomized Studies

    • S. M. Bentze
    Pages 11-26

  4. Limitations of the Bromodeoxyuridine Technique for Measurement of Tumour Proliferation

    • G. D. Wilson
    Pages 27-43

  5. Hyperfractionation

    • H. R. Withers
    Pages 45-50

  6. The Limitation of the Linear-Quadratic Model at Low Doses per Fraction

    • M. C. Joiner, B. Marples, H. Johns
    Pages 51-66

  7. The Influence of the Size of Dose on the Repair Kinetics of X-ray-Induced DNA Strand Breaks Studied in CHO Cells

    • E. Dikomey
    Pages 67-73

  8. The Fractionation Sensitivity of Malignant Melanomas

    • K. R. Trott
    Pages 75-85

  9. Radiosensivity of Tumor Cells: The Predictive Value of SF2

    • M. Baumann, A. Taghian, W. Budach
    Pages 87-98

  10. Hypoxia in Tumours: Its Relevance, Identification, and Modification

    • M. R. Horsman
    Pages 99-112

  11. The Impact of Local Tumor Control on the Outcome in Human Cancer

    • S. A. Leibel, Z. Fuks
    Pages 113-127

  12. Cell Loss in Irradiated Tumours

    • I. Brammer, H. Jung
    Pages 129-145

  13. Back Matter

    Pages 147-152
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Keywords

About this book

The impact of basic science radiobiological research is now being recognized of significant importance in clinical radiation oncology. Observations made in the laboratory using animals as'well as tissue culture have led to a better biologic understanding of techniques for altered fractionation, techniques for measuring tumor cell proliferation, the possi­ bilities and limitations of methods for evaluation of nonrandomized clinical studies in deriving time dose relationships for human tumors as well as a better understanding of repair kinetics in mammalian cells, fractionation sensitivity and the major impact oftechnologies to improve local/regional control with the subsequent impact on survival. These findings have led to changes in treatment schedules and have led to further close cooperation among the radiation oncologists and radiation biologists. Well support research efforts in radiation biology have a major and significant impact on the clinical care of the cancer patient. Studies that originated in the laboratory are now finding their way into clinical practice resulting in better local and regional control and improved number of patients surviving without disease.

Editors and Affiliations

  • Institut für Biophysik und Strahlenbiologie, Universität Hamburg, Hamburg, Germany

    Hans-Peter Beck-Bornholdt

Bibliographic Information

  • Book Title: Current Topics in Clinical Radiobiology of Tumors

  • Editors: Hans-Peter Beck-Bornholdt

  • Series Title: Medical Radiology

  • DOI: https://doi.org/10.1007/978-3-642-84918-3

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1993

  • Softcover ISBN: 978-3-642-84920-6Published: 15 December 2011

  • eBook ISBN: 978-3-642-84918-3Published: 06 December 2012

  • Series ISSN: 0942-5373

  • Series E-ISSN: 2197-4187

  • Edition Number: 1

  • Number of Pages: IX, 152

  • Number of Illustrations: 3 b/w illustrations

  • Topics: Radiotherapy, Biological and Medical Physics, Biophysics, Cancer Research

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