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Recent Advances in Cell Biology of Acute Leukemia

Impact on Clinical Diagnosis and Therapy

  • Conference proceedings
  • © 1993

Overview

Editors:
  1. Wolf-Dieter Ludwig

    1. Abt. Hämatologie/Onkologie, Universitätsklinikum Steglitz, Berlin 45, Germany

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  2. Eckhard Thiel

    1. Abt. Hämatologie/Onkologie, Universitätsklinikum Steglitz, Berlin 45, Germany

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Recent Results in Cancer Research (RECENTCANCER, volume 131)

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Table of contents (35 papers)

  1. Front Matter

    Pages I-XV
    Download chapter PDF

  3. Phenotypic Heterogeneity in Acute Leukemias: Immunological Characterization and Clinical Relevance

    1. Immunological, Ultrastructural and Molecular Features of Unclassifiable Acute Leukaemia

      • E. Matutes, V. Buccheri, R. Morilla, V. Shetty, M. Dyer, D. Catovsky
      Pages 41-52

    2. Incidence and Clinical Relevance of Myeloid Antigen-Positive Acute Lymphoblastic Leukemia

      • H. G. Drexler, W.-D. Ludwig
      Pages 53-66

    3. Myeloid-Associated Antigen Expression in Childhood Acute Lymphoblastic Leukemia

      • F. M. Fink, U. Köller, H. Mayer, O. A. Haas, E. R. Grümayer, C. Urban et al.
      Pages 67-75

    4. Contribution of Electron Microscopy to the Classification of Minimally Differentiated Acute Leukemias in Children

      • E. R. van Wering, P. Brederoo, G. J. van Staalduinen, J. van der Meulen, B. E. M. van der Linden-Schrever, J. J. M. van Dongen
      Pages 77-87

  4. Biological and Clinical Significance of Cytogenetic Abnormalities in Acute Leukemias

    1. Molecular Cytogenetic Applications in Leukemias

      • S. Knuutila
      Pages 89-101

    2. Cytogenetic Abnormalities Associated with Childhood Acute Myeloblastic Leukemia

      • O. A. Haas, M. Kronberger, L. Mayerhofer
      Pages 103-112

    3. DNA Aneuploidy in Childhood Acute Lymphoblastic Leukemia: Relation to Clinical Determinants and Prognosis within Four Consecutive BFM Trials

      • W. Hiddemann, J. Harbott, W.-D. Ludwig, J. Ritter, A. Nehmer, A. Reiter et al.
      Pages 113-121

    4. Clinical Significance of Cytogenetic Studies in Childhood Acute Lymphoblastic Leukemia: Experience of the BFM Trials

      • J. Harbott, J. Ritterbach, W.-D. Ludwig, C. R. Bartram, A. Reiter, F. Lampert
      Pages 123-132

    5. Chromosomal Abnormalities in Adult Acute Lymphoblastic Leukemia: Results of the German ALL/AUL Study Group

      • H. Rieder, W.-D. Ludwig, W. Gassmann, E. Thiel, H. Löffler, D. Hoelzer et al.
      Pages 133-148

  5. Minimal Residual Disease in Acute Leukemias: Detection and Immunotherapeutic Strategies

    1. Molecular Genetic Techniques for Detection of Minimal Residual Disease in Acute Lymphoblastic Leukemia: Possibilities and Limitations

      • C. R. Bartram
      Pages 149-155

    2. Immunophenotypic and Immunogenotypic Detection of Minimal Residual Disease in Acute Lymphoblastic Leukemia

      • J. J. M. van Dongen, T. M. Breit, H. J. Adriaansen, A. Beishuizen, H. Hooijkaas
      Pages 157-184

    3. Detection of Aberrant Antigen Expression in Acute Myeloid Leukemia by Multiparameter Flow Cytometry

      • B. Wörmann, M. Safford, S. Könemann, T. Büchner, W. Hiddemann, L. W. M. M. Terstappen
      Pages 185-196

    4. Detection of Residual Leukemic Cells in Adult Acute Lymphoblastic Leukemia by Analysis of Gene Rearrangements and Correlation with Early Relapses

      • W. U. Knauf, A. D. Ho, D. Hoelzer, E. Thiel
      Pages 197-205

    5. Interleukin-2-Based Immunotherapy in the Management of Minimal Residual Disease in Acute Leukemia Patients

      • R. Foa, G. Meloni, A. Guarini, M. Vignetti, D. Marchis, S. Tosti et al.
      Pages 207-214

    6. Preclinical Studies of T-Cell-Mediated Immune Responses Against Autologous Tumor Cells in Patients with Acute Leukemia

      • M. Notter, W.-D. Ludwig, E. Thiel
      Pages 215-222
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Keywords

About this book

The development of new techniques such as immuno­ phenotyping, cytogenetic investigations and, more recently, molecular studies has considerably increased our diagnostic repertoire and broadened our ideas about the biology of acute leukemias. While immunophenotyping with mono­ clonal antibodies has yielded increased diagnostic precision and made it possible to develop a highly reproducible classification of acute leukemias based on cell-biological features, further insights have been gained into the patho­ genetic mechanisms involved in leukemogenesis by means of cytogenetic detection of acquired structural chromosomal abnormalities. Analysis of the leukemia-associated chromo­ somal breakpoints using molecular techniques can now pinpoint many genomic sites essential for normal develop­ ment and maturation of hematopoietic cells but functionally disrupted in leukemic cells. The main goal of the international workshop that we held in Berlin with a select group of scientists and clinicians involved in leukemia research was to describe the state of the art and new developments in the immunologic, cytogenetic, and molecular characterization of acute leukemias and to discuss the clinical importance of cell­ biological features. After introductory survey lectures dealing with the immunological and molecular-biological characteristics of normal vs. malignant lymphatic and myeloid progenitor cells, the workshop centered on con­ tributions characterizing the immunophenotype and both numerical and structural chromosomal abnormalities in acute leukemias.

Editors and Affiliations

  • Abt. Hämatologie/Onkologie, Universitätsklinikum Steglitz, Berlin 45, Germany

    Wolf-Dieter Ludwig, Eckhard Thiel

Bibliographic Information

  • Book Title: Recent Advances in Cell Biology of Acute Leukemia

  • Book Subtitle: Impact on Clinical Diagnosis and Therapy

  • Editors: Wolf-Dieter Ludwig, Eckhard Thiel

  • Series Title: Recent Results in Cancer Research

  • DOI: https://doi.org/10.1007/978-3-642-84895-7

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1993

  • Softcover ISBN: 978-3-642-84897-1Published: 09 February 2012

  • eBook ISBN: 978-3-642-84895-7Published: 06 December 2012

  • Series ISSN: 0080-0015

  • Series E-ISSN: 2197-6767

  • Edition Number: 1

  • Number of Pages: XV, 407

  • Number of Illustrations: 3 illustrations in colour

  • Topics: Oncology, Hematology, Allergology, Immunology

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