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Skin Carcinogenesis in Man and in Experimental Models

  • Conference proceedings
  • © 1993

Overview

Editors:
  1. Erich Hecker

    1. Division: Mechanisms of Tumorigenesis, Research Program 3: Risk Factors of Cancer and Cancer Prevention, Deutsches Krebsforschungszentrum, Heidelberg, Germany

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  2. E. G. Jung

    1. Department of Dermatology, Mannheim Medical School, University of Heidelberg, Mannheim, Germany

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  3. F. Marks

    1. Division: Biochemistry of Tissue Specific Regulation, Research Program 2: Tumor Cell Regulation, Deutsches Krebsforschungszentrum, Heidelberg, Germany

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  4. W. Tilgen

    1. Department of Dermatology, University of Heidelberg, Heidelberg, Germany

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Part of the book series: Recent Results in Cancer Research (RECENTCANCER, volume 128)

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Table of contents (27 papers)

  1. Front Matter

    Pages I-XVIII
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  2. General Aspects

    1. Genetic Determinants in Carcinogenesis

      • J. C. Barrett
      Pages 1-13

    2. Transforming Growth Factor Regulation of Keratinocyte Growth

      • L. Dagnino, J. A. Pietenpol, E. Y. Yang, H. L. Moses
      Pages 15-29

    3. Epithelial Stem Cells, Hair Follicles, and Tumor Formation

      • R. M. Lavker, S. J. Miller, T.-T. Sun
      Pages 31-43

    4. The Skin: Initiation and Target Site of Immune Responses

      • G. Stingl
      Pages 45-57

  3. Melanocyte Carcinogenesis

    1. Melanocyte Carcinogenesis: Facts and Fancies

      • W. Tilgen
      Pages 59-67

    2. The German Melanoma Registry and Environmental Risk Factors Implied

      • C. Garbe, J. Weiß, S. Krüger, E. Garbe, P. Büttner, J. Bertz et al.
      Pages 69-89

    3. Fair Complexion and Risk of Malignant Melanoma of the Skin Based on Experience from the Danish Cancer Registry

      • A. Østerlind
      Pages 91-100

    4. Dysplastic Nevi-Dysplastic Nevus Syndromes: Clinical Features and Genetic Aspects

      • J. Weiss, C. Garbe, P. Büttner, E. G. Jung
      Pages 101-118

    5. Integrins and Melanoma Progression

      • E. H. J. Danen, G. N. P. van Muijen, P. J. M. ten Berge, D. J. Ruiter
      Pages 119-132

    6. Growth Regulation in Normal and Malignant Melanocytes

      • R. Halaban
      Pages 133-150

  4. Keratinocyte Carcinogenesis

    1. Keratinocyte Carcinogenesis: Introduction

      • I. Moll
      Pages 151-152

    2. Diversity of Epithelial Skin Tumors: Thoughts and Comments on Some Basic Principles

      • U. Wollina
      Pages 153-178

    3. Keratinocyte Alterations in Skin Tumour Development

      • I. M. Leigh, P. E. Purkis, A. Markey, P. Collins, S. Neill, C. Proby et al.
      Pages 179-191

    4. Cellular and Molecular Changes During Mouse Skin Tumor Progression

      • A. J. P. Klein-Szanto, B. Ruggeri, A. Bianchi, C. J. Conti
      Pages 193-204

    5. Influence of Aging and Malignant Transformation on Keratinocyte Gene Expression

      • M. Yaar, J. Arora, M. Garmyn, A. Gilani, B. A. Gilchrest
      Pages 205-214

    6. Molecular Mechanisms of Skin Carcinogenesis Induced by Chemicals and Ionizing Radiation

      • G. T. Bowden, M. A. Nelson, J. P. Levy, J. Finch, P. Krieg
      Pages 215-230

    7. Threshold-like Dose Response of Mouse Skin Cancer Induction by Repeated Beta Irradiation and its Relevance to Radiation-Induced Human Skin Cancer

      • H. Tanooka, A. Ootsuyama
      Pages 231-241

    8. Environmental Risk Factors for Skin Cancer

      • F. Urbach
      Pages 243-262

    9. Ultraviolet Carcinogenesis: Environmental Effects of Ozone Depletion

      • J. C. van der Leun, F. R. de Gruijl, M. Tevini, R. C. Worrest
      Pages 263-267
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Keywords

About this book

The detection of cancer risk factors and their possible avoid­ ance would most effectively contribute to the fight against cancer. Research in these areas depends to a substantial degree on in vivo experimental animal models and on epide­ miologic studies, including data from cancer registries. When the Deutsches Krebsforschungszentrum was founded in 1964, its division "Mechanisms of Tumorigenesis" and a number of other divisions became engaged in research on chemical carcinogenesis of the skin, mainly using the mouse skin as an experimental model. Their interest orig­ inated in part from investigations of the new and at that time controversial pathogenic principle of conditional car­ cinogens as represented by certain tumor promoters which are per se noncarcinogenic. During the past 25 years, conditional carcinogens in terms of tumor promoters were established as anew, nonclassical category of cancer risk factors besides the classical solitary carcinogens. In the course of this exciting period, scientists of our center started cooperative programs with clinical dermato­ logists of the University of Heidelberg at the Clinics of Dermatology in Heidelberg and Mannheim, to extend the scope of their investigations into clinical oncology and to contribute by experimental approaches to solving problems in clinical oncology. This led to a gradual shift from mere animal studies to the more direct analyses of human tumors and opened up for us a new phase of research.

Editors and Affiliations

  • Division: Mechanisms of Tumorigenesis, Research Program 3: Risk Factors of Cancer and Cancer Prevention, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Erich Hecker

  • Department of Dermatology, Mannheim Medical School, University of Heidelberg, Mannheim, Germany

    E. G. Jung

  • Division: Biochemistry of Tissue Specific Regulation, Research Program 2: Tumor Cell Regulation, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    F. Marks

  • Department of Dermatology, University of Heidelberg, Heidelberg, Germany

    W. Tilgen

Bibliographic Information

  • Book Title: Skin Carcinogenesis in Man and in Experimental Models

  • Editors: Erich Hecker, E. G. Jung, F. Marks, W. Tilgen

  • Series Title: Recent Results in Cancer Research

  • DOI: https://doi.org/10.1007/978-3-642-84881-0

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1993

  • Softcover ISBN: 978-3-642-84883-4Published: 09 February 2012

  • eBook ISBN: 978-3-642-84881-0Published: 06 December 2012

  • Series ISSN: 0080-0015

  • Series E-ISSN: 2197-6767

  • Edition Number: 1

  • Number of Pages: XVIII, 364

  • Topics: Oncology, Dermatology

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